Abstract
The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.
| Original language | English |
|---|---|
| Pages (from-to) | 611-619 |
| Number of pages | 9 |
| Journal | Mini reviews in medicinal chemistry |
| Volume | 2 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2002 |
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This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
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