Recent advances in topoisomerase I-targeting agents, camptothecin analogues.

Dae Kee Kim, Namkyu Lee

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.

Original languageEnglish
Pages (from-to)611-619
Number of pages9
JournalMini reviews in medicinal chemistry
Issue number6
StatePublished - Dec 2002


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