TY - JOUR
T1 - Recent advances in topoisomerase I-targeting agents, camptothecin analogues.
AU - Kim, Dae Kee
AU - Lee, Namkyu
PY - 2002/12
Y1 - 2002/12
N2 - The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.
AB - The present review concentrates on camptothecin (CPT) analogues, the most extensively studied topoisomerase I (topo I) inhibitors, and provides concise information on the structural features of human topo I enzyme, mechanisms of interaction of CPT with topo I, structure-activity relationship study of CPT analogues including the influence of lactone stability on antitumor activity, and recent updates of valuable CPT analogues.
UR - http://www.scopus.com/inward/record.url?scp=0038698117&partnerID=8YFLogxK
U2 - 10.2174/1389557023405530
DO - 10.2174/1389557023405530
M3 - Review article
C2 - 12370044
AN - SCOPUS:0038698117
SN - 1389-5575
VL - 2
SP - 611
EP - 619
JO - Mini reviews in medicinal chemistry
JF - Mini reviews in medicinal chemistry
IS - 6
ER -
