Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

Mi Na Rhie; Hee Taek Kim; Seo Young Jo; Luan Luong Chu; Kei Anne Baritugo; Mary Grace Baylon; Jinwon Lee; Jeong Geol Na; Lyul Ho Kim; Tae Wan Kim; Chulhwan Park; Soon Ho Hong; Jeong Chan Joo; Si Jae Park

doi:10.1007/s12257-018-0346-x

Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

Mi Na Rhie, Hee Taek Kim, Seo Young Jo, Luan Luong Chu, Kei Anne Baritugo, Mary Grace Baylon, Jinwon Lee, Jeong Geol Na, Lyul Ho Kim, Tae Wan Kim, Chulhwan Park, Soon Ho Hong, Jeong Chan Joo, Si Jae Park

Department of Chemical Engineering & Materials Science

Research output: Contribution to journal › Review article › peer-review

32 Scopus citations

Abstract

The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.

Original language	English
Pages (from-to)	48-64
Number of pages	17
Journal	Biotechnology and Bioprocess Engineering
Volume	24
Issue number	1
DOIs	https://doi.org/10.1007/s12257-018-0346-x
State	Published - 1 Feb 2019

Bibliographical note

Funding Information:
This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science and ICT (MSIT) through the National Research Foundation (NRF) of Korea (NRF-2015M1A2A2035810), the Bio & Medical Technology Development Program MSIT through the NRF of Korea (NRF-2018M3A9H3020459) and “Human Resources Program in Energy Technology” of the Korea Institute of Energy Technology Evaluation and Planning (KETEP), granted financial resource from the Ministry of Trade, Industry & Energy, Republic of Korea (No. 20174010201150).

Publisher Copyright:
© 2019, The Korean Society for Biotechnology and Bioengineering and Springer.

Keywords

Klebsiella pneumoniae
biomass
biorefinery
carbon utilization
metabolic engineering
microbial cell factory

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Rhie, M. N., Kim, H. T., Jo, S. Y., Chu, L. L., Baritugo, K. A., Baylon, M. G., Lee, J., Na, J. G., Kim, L. H., Kim, T. W., Park, C., Hong, S. H., Joo, J. C., & Park, S. J. (2019). Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries. Biotechnology and Bioprocess Engineering, 24(1), 48-64. https://doi.org/10.1007/s12257-018-0346-x

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title = "Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries",

abstract = "The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society{\textquoteright}s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.",

keywords = "Klebsiella pneumoniae, biomass, biorefinery, carbon utilization, metabolic engineering, microbial cell factory",

author = "Rhie, {Mi Na} and Kim, {Hee Taek} and Jo, {Seo Young} and Chu, {Luan Luong} and Baritugo, {Kei Anne} and Baylon, {Mary Grace} and Jinwon Lee and Na, {Jeong Geol} and Kim, {Lyul Ho} and Kim, {Tae Wan} and Chulhwan Park and Hong, {Soon Ho} and Joo, {Jeong Chan} and Park, {Si Jae}",

note = "Funding Information: This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science and ICT (MSIT) through the National Research Foundation (NRF) of Korea (NRF-2015M1A2A2035810), the Bio & Medical Technology Development Program MSIT through the NRF of Korea (NRF-2018M3A9H3020459) and “Human Resources Program in Energy Technology” of the Korea Institute of Energy Technology Evaluation and Planning (KETEP), granted financial resource from the Ministry of Trade, Industry & Energy, Republic of Korea (No. 20174010201150). Publisher Copyright: {\textcopyright} 2019, The Korean Society for Biotechnology and Bioengineering and Springer.",

year = "2019",

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doi = "10.1007/s12257-018-0346-x",

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Rhie, MN, Kim, HT, Jo, SY, Chu, LL, Baritugo, KA, Baylon, MG, Lee, J, Na, JG, Kim, LH, Kim, TW, Park, C, Hong, SH, Joo, JC & Park, SJ 2019, 'Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries', Biotechnology and Bioprocess Engineering, vol. 24, no. 1, pp. 48-64. https://doi.org/10.1007/s12257-018-0346-x

TY - JOUR

T1 - Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae

T2 - A Potential Platform Microorganism for Biorefineries

AU - Rhie, Mi Na

AU - Kim, Hee Taek

AU - Jo, Seo Young

AU - Chu, Luan Luong

AU - Baritugo, Kei Anne

AU - Baylon, Mary Grace

AU - Lee, Jinwon

AU - Na, Jeong Geol

AU - Kim, Lyul Ho

AU - Kim, Tae Wan

AU - Park, Chulhwan

AU - Hong, Soon Ho

AU - Joo, Jeong Chan

AU - Park, Si Jae

N1 - Funding Information: This work was supported by the Technology Development Program to Solve Climate Changes on Systems Metabolic Engineering for Biorefineries from the Ministry of Science and ICT (MSIT) through the National Research Foundation (NRF) of Korea (NRF-2015M1A2A2035810), the Bio & Medical Technology Development Program MSIT through the NRF of Korea (NRF-2018M3A9H3020459) and “Human Resources Program in Energy Technology” of the Korea Institute of Energy Technology Evaluation and Planning (KETEP), granted financial resource from the Ministry of Trade, Industry & Energy, Republic of Korea (No. 20174010201150). Publisher Copyright: © 2019, The Korean Society for Biotechnology and Bioengineering and Springer.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.

AB - The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.

KW - Klebsiella pneumoniae

KW - biomass

KW - biorefinery

KW - carbon utilization

KW - metabolic engineering

KW - microbial cell factory

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U2 - 10.1007/s12257-018-0346-x

DO - 10.1007/s12257-018-0346-x

M3 - Review article

AN - SCOPUS:85061279095

SN - 1226-8372

VL - 24

SP - 48

EP - 64

JO - Biotechnology and Bioprocess Engineering

JF - Biotechnology and Bioprocess Engineering

IS - 1

ER -

Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

Abstract

Bibliographical note

Keywords

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