Recent Advances in the Metabolic Engineering of Klebsiella pneumoniae: A Potential Platform Microorganism for Biorefineries

Mi Na Rhie, Hee Taek Kim, Seo Young Jo, Luan Luong Chu, Kei Anne Baritugo, Mary Grace Baylon, Jinwon Lee, Jeong Geol Na, Lyul Ho Kim, Tae Wan Kim, Chulhwan Park, Soon Ho Hong, Jeong Chan Joo, Si Jae Park

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

The production of industrial chemicals from renewable biomass resources is a promising solution to overcome the society’s dependence on petroleum and to mitigate the pollution resulting from petroleum processing. Klebsiella pneumoniae is a nutritionally versatile bacterium with numerous native pathways for the production of well-known and industrially important platform chemicals derived from various sugars. Genomic sequence analyses have shown that the K. pneumoniae genome has a high similarity with that of Escherichia coli, the most studied organism, which is used in industrial biotechnology processes for fuel and chemical production. Hence, K. pneumoniae can be considered as a promising platform microorganism that can be metabolically engineered for the high-level production of bio-based chemicals. This review highlights the substrate metabolism and the metabolic engineering strategies developed in K. pneumoniae for the production of bio-based chemicals.

Original languageEnglish
Pages (from-to)48-64
Number of pages17
JournalBiotechnology and Bioprocess Engineering
Volume24
Issue number1
DOIs
StatePublished - 1 Feb 2019

Keywords

  • Klebsiella pneumoniae
  • biomass
  • biorefinery
  • carbon utilization
  • metabolic engineering
  • microbial cell factory

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