Recent Advances in the Development of Chromophore-Based Chemosensors for Nerve Agents and Phosgene

Liyan Chen, Di Wu, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

203 Scopus citations


The extreme toxicity and ready accessibility of nerve agents and phosgene has caused an increase in the demand to develop effective systems for the detection of these substances. Among the traditional platforms utilized for this purpose, chemosensors including surface acoustic wave (SAW) sensors, enzymes, carbon nanotubes, nanoparticles, and chromophore based sensors have attracted increasing attention. In this review, we describe in a comprehensive manner recent progress that has been made on the development of chromophore-based chemosensors for detecting nerve agents (mimic) and phosgene. This review comprises two sections focusing on studies of the development of chemosensors for nerve agents (mimic) and phosgene. In each of the sections, the discussion follows a format which concentrates on different reaction sites/mechanisms involved in the sensing processes. Finally, chemosensors uncovered in these efforts are compared with those based on other sensing methods and challenges facing the design of more effective chemosensors for the detection of nerve agents (mimic) and phosgene are discussed.

Original languageEnglish
Pages (from-to)27-43
Number of pages17
JournalACS Sensors
Issue number1
StatePublished - 26 Jan 2018

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.


  • chemical warfare agents (CWAs)
  • chromophore-based chemosensors
  • colorimetric
  • nerve agents (mimic)
  • organophosphate
  • phosgene
  • phosphorylation reaction
  • ratiometric


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