Recent advances in the development of bioelectronic nose

Sang Hun Lee, Tai Hyun Park

Research output: Contribution to journalReview articlepeer-review

79 Scopus citations


The olfactory system has the ability to discriminate and identify thousands of odorant compounds at very low concentrations. Recently, many researchers have been trying to develop artificial sensing devices that are based on the olfactory system. A bioelectronic nose, which uses olfactory receptors (ORs) as sensing elements, would benefit naturally optimized molecular recognition. Accordingly, ORs can be effectively used as a biological element in bioelectronic noses. Bioelectronic nose can be classified into cell-based and protein-based biosensors. The cell-based biosensor uses living cells that express olfactory receptors as the biological sensing elements and the protein-based biosensor uses the olfactory receptor protein. The binding of odorant molecules to the ORs can be measured using various methods such as piezoelectric, optic, and electric devices. Thus, bioelectronic nose can be developed by combining the biological sensing elements with these non-biological devices. The application of bioelectronic nose in a wide range of different scientific and medical fields is essentially dependent on the development of highly sensitive and selective biosensors. These sensor systems for the rapid detection of specific odorants are crucial for environmental monitoring, anti-bioterrorism, disease diagnostics, and food safety. In this article, we reviewed recent advances in the development of bioelectronic nose.

Original languageEnglish
Pages (from-to)22-29
Number of pages8
JournalBiotechnology and Bioprocess Engineering
Issue number1
StatePublished - Feb 2010

Bibliographical note

Funding Information:
This work was supported by the Korea


  • Bioelectronic nose
  • Olfactory biosensor
  • Olfactory receptor
  • Olfactory system


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