Recent Advances in Systems Metabolic Engineering Strategies for the Production of Biopolymers

Yu Jung Sohn, Hee Taek Kim, Seo Young Jo, Hye Min Song, Kei Anne Baritugo, Jiwon Pyo, Jong il Choi, Jeong Chan Joo, Si Jae Park

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Biopolymers consisting of at least one monomer, which are produced from renewable carbon sources, are being highly sought out since ubiquitous plastics are mainly produced from petrochemical processes causing severe environmental pollution. Therefore, the development of microbial cell factories, which can efficiently synthesize diverse types of monomers and polymers, is also becoming increasingly important. The applicability of traditional metabolic engineering strategies has extended with the combination of systems biology, synthetic biology, and evolutionary engineering in a systemic and versatile manner, and are collectively termed as systems metabolic engineering. Accordingly, recent advances in biotechnology have paved the way for enabling the production of an increasing number of monomers and polymers by providing several tools and strategies associated with systems metabolic engineering. In this review, we have focused on the substantial efforts made on the development of different approaches of systems metabolic engineering, particularly based on synthetic biology and evolutionary engineering, for the efficient production of monomers and polymers.

Original languageEnglish
Pages (from-to)848-861
Number of pages14
JournalBiotechnology and Bioprocess Engineering
Issue number6
StatePublished - Dec 2020

Bibliographical note

Funding Information:
This research was supported by the Bio & Medical Technology Development Program of the National Research Foundation (NRF) funded by the Korean government (MSIT) (NRF-2020M3A9I5037888), the Basic Science Research Program (NRF-2020R1F1A1070249), and the NRF grant funded by the MSIT (NRF-2020R1A5A1019631).

Publisher Copyright:
© 2020, The Korean Society for Biotechnology and Bioengineering and Springer.


  • biopolymers
  • evolutionary engineering
  • metabolic engineering
  • synthetic biology
  • systems metabolic engineering


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