Recent advances in nonalcoholic fatty liver disease metabolomics

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Abstract

The clinical phenotypes of nonalcoholic fatty liver disease (NAFLD) encompass from simple steatosis to nonalcoholic steatohepatitis (NASH) with varying degrees of fibrosis or cirrhosis. Liver biopsy has been the standard to diagnose NASH. However, there has been strong need for precise and accurate noninvasive tests because of invasiveness and sampling variability of biopsy. Metabolomics has drawn attention as a promising diagnostic methodology in the field of NAFLD, particularly to unravel metabolic alterations which plays relevant roles in the progression of NASH. There have been numerous metabolomics researches to find new biomarker of NASH in the last decade, fueled by the recent advances in the metabolomics methodology. This review briefly covers recent research advances on the lipidomics, amino acids and bile acid metabolomics regarding continuing attempts to discover relevant biomarkers for NASH.

Original languageEnglish
Pages (from-to)553-559
Number of pages7
JournalClinical and molecular hepatology
Volume27
Issue number4
DOIs
StatePublished - Oct 2021

Keywords

  • Amino acids
  • Bile acids and salts
  • Fatty liver
  • Lipids
  • Phenotype

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