Recent advances in biomedical applications of organic fluorescence materials with reduced singlet–triplet energy gaps

Van Nghia Nguyen, Ajay Kumar, Min Hyung Lee, Juyoung Yoon

Research output: Contribution to journalReview articlepeer-review

73 Scopus citations

Abstract

Purely organic, thermally activated delayed fluorescence (TADF) materials have recently emerged as novel and attractive organic luminescent materials for use in many research fields. Motivated by the unique features of TADF fluorophores, most notably their long-lived delayed fluorescence and high triplet formation, many organic TADF fluorophores have been developed for biomedical applications. In this review, we briefly summarize recent progress in the development of intelligent TADF probes, ranging from single molecules to delicate nanomaterials, for time-resolved fluorescence imaging and biosensing in biology and medicine. Moreover, recent strategies for designing novel photosensitizers (PSs) based on donor–acceptor systems with reduced singlet–triplet energy gaps (ΔEST) for photodynamic therapy of cancer are also introduced. Finally, the main challenges of and prospects for organic molecules with reduced ΔEST for biomedical applications are discussed.

Original languageEnglish
Article number213545
JournalCoordination Chemistry Reviews
Volume425
DOIs
StatePublished - 15 Dec 2020

Bibliographical note

Publisher Copyright:
© 2020 Elsevier B.V.

Keywords

  • Fluorescence probes
  • Photodynamic therapy
  • Photosensitizer
  • Thermally activated delayed fluorescence
  • Time-resolved fluorescence imaging

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