Real-world data for health technology assessment for reimbursement decisions in Asia: Current landscape and a way forward

Jing Lou, Sarin Kc, Kai Yee Toh, Saudamini Dabak, Amanda Adler, Jeonghoon Ahn, DIana Beatriz S. Bayani, Kelvin Chan, Dechen Choiphel, Brandon Chua, Anne Julienne Genuino, Anna Melissa Guerrero, Brendon Kearney, Lydia Wenxin Lin, Yuehua Liu, Ryota Nakamura, Fiona Pearce, Shankar Prinja, Raoh Fang Pwu, Asrul Akmal ShafieBinyan Sui, Auliya Suwantika, Yot Teerawattananon, Sean Tunis, Hui Min Wu, John Zalcberg, Kun Zhao, Wanrudee Isaranuwatchai, Hwee Lin Wee

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

There is growing interest globally in using real-world data (RWD) and real-world evidence (RWE) for health technology assessment (HTA). Optimal collection, analysis, and use of RWD/RWE to inform HTA requires a conceptual framework to standardize processes and ensure consistency. However, such framework is currently lacking in Asia, a region that is likely to benefit from RWD/RWE for at least two reasons. First, there is often limited Asian representation in clinical trials unless specifically conducted in Asian populations, and RWD may help to fill the evidence gap. Second, in a few Asian health systems, reimbursement decisions are not made at market entry; thus, allowing RWD/RWE to be collected to give more certainty about the effectiveness of technologies in the local setting and inform their appropriate use. Furthermore, an alignment of RWD/RWE policies across Asia would equip decision makers with context-relevant evidence, and improve timely patient access to new technologies. Using data collected from eleven health systems in Asia, this paper provides a review of the current landscape of RWD/RWE in Asia to inform HTA and explores a way forward to align policies within the region. This paper concludes with a proposal to establish an international collaboration among academics and HTA agencies in the region: the REAL World Data In ASia for HEalth Technology Assessment in Reimbursement (REALISE) working group, which seeks to develop a non-binding guidance document on the use of RWD/RWE to inform HTA for decision making in Asia.

Original languageEnglish
Pages (from-to)474-480
Number of pages7
JournalInternational Journal of Technology Assessment in Health Care
Volume36
Issue number5
DOIs
StatePublished - Oct 2020

Keywords

  • Asia
  • Cost-effectiveness analysis
  • Health technology assessment
  • Real-world data
  • Real-world evidence

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