Abstract
Highly luminescent europium complexes modified mesoporous silica particles (MSP) were synthesized as an imaging probes for both in-vitro diagnostic and in-vivo cellular tracking agents. Europium β-diketone chelates (4,4,4-trifluoro-l-(2-thienyl)-l,3-butanedione) trioctylphosphine europium (III) (Eu(TTA)3(P(Oct)3)3) were incorporated inside the nanocavities that existed in hierarchical MSP (Eu@MSP). The MSP and Eu@MSP on mouse bone marrow-derived macrophages (BMDMs) did not show any toxic effect. The MSP and Eu@MSP in the BMDMs were found at cytoplasm without any degradation and immunogenicity. However, both pro-and antiinflammatory cytokines of macrophages were significantly increased when lipopolysaccharide and a high concentration (100 μg/mL) of MSP and Eu@MSP were treated simultaneously.
Original language | English |
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Article number | 343 |
Pages (from-to) | 1-16 |
Number of pages | 16 |
Journal | Nanomaterials |
Volume | 11 |
Issue number | 2 |
DOIs | |
State | Published - Feb 2021 |
Keywords
- Beta-diketone
- Europium complex
- Inflammation
- Live cell image
- Mesoporous silica