Real-time temperature monitoring with fiber Bragg grating sensor during diffuser-assisted laser-induced interstitial thermotherapy

Ngot Thi Pham, Seul Lee Lee, Suhyun Park, Yong Wook Lee, Hyun Wook Kang

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32 Scopus citations


High-sensitivity temperature sensors have been used to validate real-time thermal responses in tissue during photothermal treatment. The objective of the current study was to evaluate the feasible application of a fiber Bragg grating (FBG) sensor for diffuser-assisted laser-induced interstitial thermotherapy (LITT) particularly to treat tubular tissue disease. A 600-μm core-diameter diffuser was employed to deliver 980-nm laser light for coagulation treatment. Both a thermocouple and a FBG were comparatively tested to evaluate temperature measurements in ex vivo liver tissue. The degree of tissue denaturation was estimated as a function of irradiation times and quantitatively compared with light distribution as well as temperature development. At the closer distance to a heat source, the thermocouple measured up to 41% higher maximum temperature than the FBG sensor did after 120-s irradiation (i.e., 98.7°C ± 6.1°C for FBG versus 131.0°C ± 5.1°C for thermocouple; p < 0.001). Ex vivo porcine urethra tests confirmed the real-time temperature measurements of the FBG sensor as well as consistently circumferential tissue denaturation after 72-s irradiation (coagulation thickness -2.2 ± 0.3 mm). The implementation of FBG can be a feasible sensing technique to instantaneously monitor the temperature developments during diffuser-assisted LITT for treatment of tubular tissue structure.

Original languageEnglish
Article number045008
JournalJournal of Biomedical Optics
Issue number4
StatePublished - 1 Apr 2017

Bibliographical note

Publisher Copyright:
© 2017 Society of Photo-Optical Instrumentation Engineers (SPIE).


  • coagulation tissue
  • diffusing fiber
  • fiber Bragg grating temperature sensor
  • laser-induced interstitial thermotherapy


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