Reactive oxygen species and tumor metastasis

Doo Jae Lee, Sang Won Kang

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


The migration and invasion of cancer cells are the first steps in metastasis. Through a series of cellular responses, including cytoskeletal reorganization and degradation of the extracellular matrix, cancer cells are able to separate from the primary tumor and metastasize to distant locations in the body. In cancer cells, reactive oxygen species (ROS) play important roles in the migration and invasion of cells. Stimulation of cell surface receptors with growth factors and integrin assembly generates ROS, which relay signals from the cell surface to important signaling proteins. ROS then act within cells to promote migration and invasion. In this review, we collect recent evidence pointing towards the involvement of ROS in tumor metastasis and discuss the roles of ROS at different stages during the process of cancer cell migration, invasion and epithelial-mesenchymal transition.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalMolecules and Cells
Issue number2
StatePublished - Feb 2013

Bibliographical note

Funding Information:
dependent invasive growth and vasculogenic mimicry in mela-ACKNOWLEDGMENTS noma cells. Free Radic. Biol. Med. 51, 893-904. This study was supported by the Drug Target Validation Pro-and Murray, G.I.(2004). Matrix metalloproteinase/tissue inhibi-Curran, S., Dundas, S.R., Buxton, J., Leeman, M.F., Ramsay, R., gram (2011-0030195) and the Research Center for Cellular tors of matrix metalloproteinase phenotype identifiespoor prog- Homeostasis (201 2R1 A5A1 048236) of the National Research nosis colorectal cancers. Clin. Cancer Res. 10, 8229-8234. Foundation funded by the Korean government (Ministry of Edu-Dong, R., Wang, Q., He, X.L., Chu, Y.K., Lu, J.G., and Ma, Q.J. cation and Science Technology). This work was partly sup-(2007). Role of nuclear factor kappa B and reactive oxygen ported by the intramural GT5 grants from Ewha Womans Uni-mesenchymal transition of MCF-7 cells. Braz. J. Med. Biol. Res.speciesinthetumor necrosis factor-alpha-inducedepithelial- versity. D. J. Lee was supported by a RP-Grant 201 1 of Ewha Womans University. Giannoni, E., Parri, M., and Chiarugi, P. (2012). EMT and oxidativeRETRACTED40, 107 1-1078. stress: a bidirectional interplay affecting tumor malignancy. REFERENCES Gloire, G., Legrand-Poels, S., and Piette, J. (2006). NF-kappaBAntioxid. Redox Signal.16, 1248-1263.


  • EMT
  • ROS
  • cancer
  • invasion
  • migration


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