Ratiometric Two-Photon Fluorescent Probe for Detecting and Imaging Hypochlorite

Yen Leng Pak, Sang Jun Park, Qingling Xu, Hwan Myung Kim, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

82 Scopus citations


The ratiometric fluorescent probe B6S, which contains pyrene as a fluorophore and imidazoline-2-thione as a reactive site, was developed for detection of hypochlorite (OCl-). B6S displays a high specificity toward OCl- in contrast to other reactive oxygen species and reactive nitrogen species. The probe has a low detection limit and operates under biological conditions. Moreover, the low cytotoxicity of B6S enables it to be utilized effectively for OCl- imaging in living cells and tissues by using two-photon microscopy. The findings indicate that B6S has the capability of serving as a probe to explore the biological functions of OCl- in living systems.

Original languageEnglish
Pages (from-to)9510-9514
Number of pages5
JournalAnalytical Chemistry
Issue number15
StatePublished - 7 Aug 2018


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