Ratiometric fluorescent probes for detection of intracellular singlet oxygen

Dayoung Song; Somin Cho; Yejee Han; Youngmin You; Wonwoo Nam

doi:10.1021/ol401421r

Ratiometric fluorescent probes for detection of intracellular singlet oxygen

Dayoung Song, Somin Cho, Yejee Han, Youngmin You, Wonwoo Nam

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70 Scopus citations

Abstract

We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (¹O₂). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with ¹O₂, producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous ¹O₂ in macrophage cells.

Original language	English
Pages (from-to)	3582-3585
Number of pages	4
Journal	Organic Letters
Volume	15
Issue number	14
DOIs	https://doi.org/10.1021/ol401421r
State	Published - 19 Jul 2013

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title = "Ratiometric fluorescent probes for detection of intracellular singlet oxygen",

abstract = "We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (1O2). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with 1O2, producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous 1O2 in macrophage cells.",

author = "Dayoung Song and Somin Cho and Yejee Han and Youngmin You and Wonwoo Nam",

year = "2013",

month = jul,

day = "19",

doi = "10.1021/ol401421r",

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journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

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T1 - Ratiometric fluorescent probes for detection of intracellular singlet oxygen

AU - Song, Dayoung

AU - Cho, Somin

AU - Han, Yejee

AU - You, Youngmin

AU - Nam, Wonwoo

PY - 2013/7/19

Y1 - 2013/7/19

N2 - We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (1O2). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with 1O2, producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous 1O2 in macrophage cells.

AB - We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (1O2). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with 1O2, producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous 1O2 in macrophage cells.

UR - https://www.scopus.com/pages/publications/84880544100

U2 - 10.1021/ol401421r

DO - 10.1021/ol401421r

M3 - Article

C2 - 23808624

AN - SCOPUS:84880544100

SN - 1523-7060

VL - 15

SP - 3582

EP - 3585

JO - Organic Letters

JF - Organic Letters

IS - 14

ER -

Ratiometric fluorescent probes for detection of intracellular singlet oxygen

Abstract

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