Abstract
We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (1O2). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with 1O2, producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous 1O2 in macrophage cells.
Original language | English |
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Pages (from-to) | 3582-3585 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 15 |
Issue number | 14 |
DOIs | |
State | Published - 19 Jul 2013 |