Ratiometric fluorescent probes for detection of intracellular singlet oxygen

Dayoung Song, Somin Cho, Yejee Han, Youngmin You, Wonwoo Nam

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


We have developed a series of molecular probes for the fluorescent detection of singlet dioxygen (1O2). The probes, based on asymmetrically substituted 1,3-diarylisobenzofurans, undergo the [2 + 4] cycloaddition reaction with 1O2, producing ratiometric fluorescent responses. Two-photon fluorescence microscope experiments demonstrated the biological utility of the probes for the visualization of endogenous 1O2 in macrophage cells.

Original languageEnglish
Pages (from-to)3582-3585
Number of pages4
JournalOrganic Letters
Issue number14
StatePublished - 19 Jul 2013


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