Rat lung peroxiredoxins I and II are differentially regulated during development and by hyperoxia

Han Suk Kim, Sang Won Kang, Sue Goo Rhee, Linda Biadasz Clerch

Research output: Contribution to journalArticlepeer-review

40 Scopus citations


Peroxiredoxin I (Prx I) and peroxiredoxin II (Prx II) are found in abundance in the cytoplasm of cells and catalyze the reduction of hydrogen peroxide with the use of electrons provided by thioredoxin. Here we examined Prx I and Prx II expression in rat lung during perinatal development and in response to hyperoxia. Prx I protein increased during late gestation and after birth fell to adult levels; conversely, Prx I mRNA increased after birth. Prx II protein concentration was unchanged in the perinatal period, but Prx II mRNA increased after birth. In response to hyperoxia begun on postnatal day 4, there was no change in Prx II expression; however, Prx I mRNA, protein, and enzymatic activity increased significantly. These data show that 1) Prx I and Prx II are developmentally regulated at the level of translational efficiency and 2) Prx I, but not Prx II, is inducible and is upregulated during the late-gestational preparation for the oxidative stress experienced by the lung at birth and during exposure to hyperoxia in the neonatal period.

Original languageEnglish
Pages (from-to)L1212-L1217
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Issue number6 24-6
StatePublished - 2001


  • Antioxidant enzyme
  • Perinatal development
  • Thiol-specific antioxidant
  • Thioredoxin peroxidase


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