Rapid, specific, and ultrasensitive fluorogenic sensing of phosgene through an enhanced PeT mechanism

Tae Il Kim, Dami Kim, Jean Bouffard, Youngmi Kim

Research output: Contribution to journalArticlepeer-review

43 Scopus citations

Abstract

We report the design of an enhanced PeT-based fluorogenic phosgene probe 1-CN comprising a BODIPY fluorescence reporter, and a catechol quencher at the meso-position acting as the phosgene reaction site. The fluorescent catechol-derived probe 1-CN specifically reacts with phosgene to result in a cyclic carbonate ester. The fast (< 3 s) reaction suppresses a reductive PeT quenching process, leading to a fluorescence turn-on signal (F/F0 up to ca. 1300). The high sensitivity (LOD = 24 pM) of the probe is achieved by the precise adjustment of the energy levels of the frontier orbitals involved in the PeT.

Original languageEnglish
Pages (from-to)458-462
Number of pages5
JournalSensors and Actuators, B: Chemical
Volume283
DOIs
StatePublished - 15 Mar 2019

Bibliographical note

Funding Information:
This research was supported by National Research Foundation of Korea (NRF) grants funded by the Korean government (MSIP) ( NRF-2017M3D9A1073769 , NRF-2018R1D1A1B07044894 , and NRF-2015R1A5A1008958 ).

Publisher Copyright:
© 2018 Elsevier B.V.

Keywords

  • BODIPY
  • Fluorescent turn-on probe
  • Phosgene
  • Photoinduced electron transfer (PeT)
  • Sensing

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