Radioisotope carrying polyethylene oxide - Polycaprolactone copolymer micelles for targetable bone imaging

Yoon Jeong Park, Jue Yeon Lee, Young Soo Chang, Jae Min Jeong, Jun Key Chung, Myung Chul Lee, Kyoung Bae Park, Seung Jin Lee

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


The aim of this research is to develop polymeric micelle system as a targetable bone imaging carriers without nonspecific phagocytosis which is made of polyethylene oxide (PEO) and polycaprolactone (PCL). Diamino-PEO, which has two amino groups in its structure, was used to conjugate both PCL and ligand for specific radioisotope. PCL was conjugated to one amino group of diamino-PEO by using diaminohexyl cyclocarbodiimide (DCC), coupling agent. Hydroxyphenylpropionic acid (HPP), diethylenetriamine pentaacetic acid (DTPA) and mercaptoacetyl glycine glycidyl glycine (MAG3), as ligands for specific radioisotopes, were coupled to the rest of amino group of diamino-PEO by the same method as described. Formation of ligand-conjugated block copolymers, critical micelle concentration (CMC) of the copolymers, hydrodynamic radii, and morphology of the micelles were investigated. Besides, 125I-labelling efficiency and biodistribution of the micelles were examined. PEO-PCL block copolymer micelles demonstrated CMC of 25mg/l and size of 60nm, which may be adequate for blood vessel and bone imaging. 125I-labelling efficiency was above 90% and was more stable at human serum for 24h. 125I-labelled polymeric micelles showed higher blood maintenance and bone uptake when compared to stannous colloid, used as a control. A noticeable decrease in liver or spleen uptake could be achieved by the micelles. Therefore, radioisotope carrying PEO-PCL micelle system was suggested as a useful tool for effective diagnostic bone targeting and imaging.

Original languageEnglish
Pages (from-to)873-879
Number of pages7
Issue number3
StatePublished - 2002

Bibliographical note

Funding Information:
This research was supported by the grant of Nuclear Energy R & D program from the Ministry of Science and Technology, Korea.


  • Bone imaging
  • Bone targeting
  • Polycaprolactone
  • Polyethylene oxide
  • Polymeric micelle
  • Radioisotope carrier


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