Radiation therapy for anal squamous cell carcinoma: A retrospective multicenter study

Hyeon Kang Koh, Kyubo Kim, Won Il Jang, Chang Hoon Song, Ah Ram Chang, Hae Jin Park, Kyung Su Kim, Ji Hyun Chang, Mi Sook Kim

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Aim: To analyze the treatment outcomes, patterns of failures and prognostic factors for patients with anal cancer treated with radiotherapy (RT). Materials and Methods: Between January 2000 and December 2015, 83 patients with anal squamous cell carcinoma were treated with definitive RT. The median RT dose applied to the primary carcinoma site was 55 (range=45-64) Gy. Seventy-six patients (91.6%) received concurrent chemotherapy, and the most common regimen was 5-fluorouracil plus mitomycin C. Results: The median age of patients was 64 (range=36-86) years, and there were 21 males and 62 females. The overall complete remission rate was 89.2%. The median duration of follow-up was 51 (range=3-173) months. The actuarial 5-year overall, progression-free survival (PFS), locoregional progression-free, and distant metastasis-free survival rates were 85.0%, 70.4%, 78.2%, and 82.6%, respectively. On multivariate analysis, eventual treatment response was the only prognostic factor for overall (p=0.023) and progression-free (p<0.001) survival.

Original languageEnglish
Pages (from-to)6931-6938
Number of pages8
JournalAnticancer Research
Issue number12
StatePublished - Dec 2018

Bibliographical note

Publisher Copyright:
© 2018 International Institute of Anticancer Research. All rights reserved.


  • Anal cancer
  • Pattern of failure
  • Prognostic factor
  • Radiotherapy
  • Treatment outcome


Dive into the research topics of 'Radiation therapy for anal squamous cell carcinoma: A retrospective multicenter study'. Together they form a unique fingerprint.

Cite this