Quinone oxidoreductase (NQO1) plays a key role in the cellular antioxidant defense by detoxifying quinine derivatives. Case-control association study of the possible relationship between the NQO1 gene polymorphism and mood disorders (patients with major depressive disorder, n = 61; patients with bipolar I disorder, n = 80; control, n = 106) was carried out using PCR-based techniques. These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders.
Bibliographical noteFunding Information:
This study was supported by a grant (KRF-2004-003-E00145) from the Korea Research Foundation. The authors express their sincere gratitude to all the patients who participated in the study.
- Mood disorder
- NQO1 gene