Quinone oxidoreductase (NQO1) gene polymorphism may not confer a susceptibility to mood disorders

Chi Un Pae, Soo Jung Yoon, Ashwin A. Patkar, Jung Jin Kim, Chul Lee, In Ho Paik

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Quinone oxidoreductase (NQO1) plays a key role in the cellular antioxidant defense by detoxifying quinine derivatives. Case-control association study of the possible relationship between the NQO1 gene polymorphism and mood disorders (patients with major depressive disorder, n = 61; patients with bipolar I disorder, n = 80; control, n = 106) was carried out using PCR-based techniques. These preliminary results showed that the NQO1 gene polymorphism was not related to a susceptibility to mood disorders.

Original languageEnglish
Pages (from-to)83-86
Number of pages4
JournalPsychiatry Research
Volume153
Issue number1
DOIs
StatePublished - 30 Sep 2007

Bibliographical note

Funding Information:
This study was supported by a grant (KRF-2004-003-E00145) from the Korea Research Foundation. The authors express their sincere gratitude to all the patients who participated in the study.

Keywords

  • Mood disorder
  • NQO1 gene
  • Polymorphism

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