Quetiapine modulates functional connectivity in brain aggression networks

Martin Klasen, Mikhail Zvyagintsev, Michael Schwenzer, Krystyna A. Mathiak, Pegah Sarkheil, René Weber, Klaus Mathiak

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Aggressive behavior is associated with dysfunctions in an affective regulation network encompassing amygdala and prefrontal areas such as orbitofrontal (OFC), anterior cingulate (ACC), and dorsolateral prefrontal cortex (DLPFC). In particular, prefrontal regions have been postulated to control amygdala activity by inhibitory projections, and this process may be disrupted in aggressive individuals. The atypical antipsychotic quetiapine successfully attenuates aggressive behavior in various disorders; the underlying neural processes, however, are unknown. A strengthened functional coupling in the prefrontal-amygdala system may account for these anti-aggressive effects. An inhibition of this network has been reported for virtual aggression in violent video games as well. However, there have been so far no in-vivo observations of pharmacological influences on corticolimbic projections during human aggressive behavior. In a double-blind, placebo-controlled study, quetiapine and placebo were administered for three successive days prior to an fMRI experiment. In this experiment, functional brain connectivity was assessed during virtual aggressive behavior in a violent video game and an aggression-free control task in a non-violent modification. Quetiapine increased the functional connectivity of ACC and DLPFC with the amygdala during virtual aggression, whereas OFC-amygdala coupling was attenuated. These effects were observed neither for placebo nor for the non-violent control. These results demonstrate for the first time a pharmacological modification of aggression-related human brain networks in a naturalistic setting. The violence-specific modulation of prefrontal-amygdala networks appears to control aggressive behavior and provides a neurobiological model for the anti-aggressive effects of quetiapine. •Quetiapine modulates corticolimbic aggression-related circuits.•Quetiapine effects on prefrontal areas are aggression-specific.•Changes in brain aggression networks parallel effects on aggressive feelings.

Original languageEnglish
Pages (from-to)20-26
Number of pages7
StatePublished - 5 Jul 2013

Bibliographical note

Funding Information:
This work was supported by unrestricted grants from the German Research Foundation (Deutsche Forschungsgemeinschaft (DFG), IRTG 1328 and MA 2631/4-1 ), AstraZeneca GmbH (Study Code D1449L00032 ), and the ICCR Aachen (N4-2) .


  • Aggression
  • Amygdala
  • Anterior cingulate cortex
  • Quetiapine
  • Serotonin
  • Video game


Dive into the research topics of 'Quetiapine modulates functional connectivity in brain aggression networks'. Together they form a unique fingerprint.

Cite this