Quantitative screening for endocrine-disrupting bisphenol A in consumer and household products using NanoAptamer assay

Hyun Jeong Lim, Eun Hee Lee, Sang Don Lee, Yeomin Yoon, Ahjeong Son

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

The NanoAptamer assay is a bisphenol A (BPA) quantification method that uses magnetic beads, quantum dot nanoparticles, and a BPA-specific aptamer. In this study, screening of various consumer and household products for BPA was demonstrated utilizing the NanoAptamer assay. First, the experimental conditions suitable for BPA detection using the NanoAptamer assay were examined in terms of incubation time, temperature, and buffer composition. The range of BPA quantification via the NanoAptamer assay was determined to be 0.005–1000 ng/mL of BPA. The selectivity was confirmed by detecting BPA in an analog mixture containing bisphenol S and bisphenol F. Finally, a leaching experiment using 20 consumer and household products classified into 4 categories was performed to demonstrate the capability of the NanoAptamer assay for BPA detection. The experiment was validated by high-performance liquid chromatography analysis (correlation coefficient, r = 0.99).

Original languageEnglish
Pages (from-to)72-80
Number of pages9
JournalChemosphere
Volume211
DOIs
StatePublished - Nov 2018

Keywords

  • Aptamer
  • Aptasensor
  • Bisphenol A
  • Endocrine disrupting chemicals
  • Quantum dots

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