Quantitative investigations on thermal response of adipose tissue to focused ultrasonic energy

Hanjae Pyo; Suhyun Park; Jae Hyun Jung; Sung Min Kim; Hyun Wook Kang

doi:10.7567/JJAP.56.07JF03

Quantitative investigations on thermal response of adipose tissue to focused ultrasonic energy

Hanjae Pyo, Suhyun Park, Jae Hyun Jung, Sung Min Kim, Hyun Wook Kang

Electronic and Electrical Engineering

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

Thermal responses of adipose tissue to high intensity focused ultrasound (HIFU) were quantitatively evaluated for effective clinical lipolysis. A single-element HIFU transducer (4MHz and 4.5mm focal depth) was used in a linear motion to thermally treat the tissue at various acoustic energy densities and treatment gaps. Both interstitial temperature rise and denatured lesions increased with the energy density (up to 21.1 + 1.9K and 0.40 + 0.15mm²). No thermal overlapping was observed due to selective application of the ultrasonic beams. The optimization of noninvasive HIFU treatment parameters may ensure clinical outcomes of HIFU-assisted lipolysis in terms of efficacy and safety.

Original language	English
Article number	07JF03
Journal	Japanese Journal of Applied Physics
Volume	56
Issue number	7
DOIs	https://doi.org/10.7567/JJAP.56.07JF03
State	Published - Jul 2017

Bibliographical note

Funding Information:
This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant Number HI16C1017).

Publisher Copyright:
© 2017 The Japan Society of Applied Physics.

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title = "Quantitative investigations on thermal response of adipose tissue to focused ultrasonic energy",

abstract = "Thermal responses of adipose tissue to high intensity focused ultrasound (HIFU) were quantitatively evaluated for effective clinical lipolysis. A single-element HIFU transducer (4MHz and 4.5mm focal depth) was used in a linear motion to thermally treat the tissue at various acoustic energy densities and treatment gaps. Both interstitial temperature rise and denatured lesions increased with the energy density (up to 21.1 + 1.9K and 0.40 + 0.15mm2). No thermal overlapping was observed due to selective application of the ultrasonic beams. The optimization of noninvasive HIFU treatment parameters may ensure clinical outcomes of HIFU-assisted lipolysis in terms of efficacy and safety.",

author = "Hanjae Pyo and Suhyun Park and Jung, {Jae Hyun} and Kim, {Sung Min} and Kang, {Hyun Wook}",

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AU - Pyo, Hanjae

AU - Park, Suhyun

AU - Jung, Jae Hyun

AU - Kim, Sung Min

AU - Kang, Hyun Wook

N1 - Funding Information: This research was supported by a grant of the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health and Welfare, Republic of Korea (Grant Number HI16C1017). Publisher Copyright: © 2017 The Japan Society of Applied Physics.

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N2 - Thermal responses of adipose tissue to high intensity focused ultrasound (HIFU) were quantitatively evaluated for effective clinical lipolysis. A single-element HIFU transducer (4MHz and 4.5mm focal depth) was used in a linear motion to thermally treat the tissue at various acoustic energy densities and treatment gaps. Both interstitial temperature rise and denatured lesions increased with the energy density (up to 21.1 + 1.9K and 0.40 + 0.15mm2). No thermal overlapping was observed due to selective application of the ultrasonic beams. The optimization of noninvasive HIFU treatment parameters may ensure clinical outcomes of HIFU-assisted lipolysis in terms of efficacy and safety.

AB - Thermal responses of adipose tissue to high intensity focused ultrasound (HIFU) were quantitatively evaluated for effective clinical lipolysis. A single-element HIFU transducer (4MHz and 4.5mm focal depth) was used in a linear motion to thermally treat the tissue at various acoustic energy densities and treatment gaps. Both interstitial temperature rise and denatured lesions increased with the energy density (up to 21.1 + 1.9K and 0.40 + 0.15mm2). No thermal overlapping was observed due to selective application of the ultrasonic beams. The optimization of noninvasive HIFU treatment parameters may ensure clinical outcomes of HIFU-assisted lipolysis in terms of efficacy and safety.

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Quantitative investigations on thermal response of adipose tissue to focused ultrasonic energy

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