Quantitative evaluation of the relative cell permeability of peptoids and peptides

Yong Uk Kwon, Thomas Kodadek

Research output: Contribution to journalArticlepeer-review

147 Scopus citations

Abstract

We evaluated quantitatively the relative cell permeability of peptoids and peptides using a cell-based reporter gene-based assay. Generally, peptoids were much more cell permeable than the corresponding peptides, though the difference decreased with increasing length. These results suggest that peptoids may be useful reagents for manipulating the activities of intracellular proteins.

Original languageEnglish
Pages (from-to)1508-1509
Number of pages2
JournalJournal of the American Chemical Society
Volume129
Issue number6
DOIs
StatePublished - 14 Feb 2007

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