Quantitative electroencephalographic (qEEG) correlates of craving during virtual reality therapy in alcohol-dependent patients

Sang Hoon Lee, Doug Hyun Han, Seman Oh, In Kyoon Lyoo, Young Sik Lee, Perry F. Renshaw, Scott E. Lukas

Research output: Contribution to journalArticlepeer-review

63 Scopus citations


Virtual reality (VR) is an evolving technology that is being applied to treat a wide range of medical and psychiatric diseases. A virtual reality therapy (VRT) with multisensory stimulation has been applied to patients with alcohol dependence (ADP). We hypothesized that the VRTP for alcohol dependence would reduce the craving for alcohol and increase alpha wave activity in frontal areas of individuals with ADP. Twenty ADP and eighteen ADP were exposed to a series of 10 VRTP sessions (VRTP-ADP) and cognitive behavioral therapy (nVRTP-ADP), respectively. Fifteen healthy controls were exposed to VRTP for comparing the changes of craving and EEG during all three phases of VRTP. The VRTP-ADP exhibited a greater decrease in craving after the 10th VRTP session, when compared to the nVRTP-ADP. Compared to the healthy control subjects, VRTP-ADP group showed higher magnitude of the change in craving throughout VRTP sessions. These results suggest that VRTP may be useful as an adjunct to treating alcohol dependence but may also serve as an evaluation tool to identify high-risk patients. Crown

Original languageEnglish
Pages (from-to)393-397
Number of pages5
JournalPharmacology Biochemistry and Behavior
Issue number3
StatePublished - Jan 2009

Bibliographical note

Funding Information:
We are thankful for the technical help of Blue Media Technology Co., Ltd., Korea. This research was supported by a Research Grant for alcohol treatment by Grants from Seo Cheon foundation 2006, Korea and NIDA Grants DA015116 and DA003H3.


  • Alcohol dependence
  • Craving
  • EEG
  • Frontal cortex
  • Virtual reality


Dive into the research topics of 'Quantitative electroencephalographic (qEEG) correlates of craving during virtual reality therapy in alcohol-dependent patients'. Together they form a unique fingerprint.

Cite this