Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging

Suhyun Park; Scott Dianis; Kai E. Thomenius; Carl L. Chalek; K. Wayne Rigby; Larry Mo; Feng Lin; Lihong Pan; Anne L. Hall; Flemming Forsberg

doi:10.1109/ULTSYM.2011.0155

Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging

Suhyun Park, Scott Dianis, Kai E. Thomenius, Carl L. Chalek, K. Wayne Rigby, Larry Mo, Feng Lin, Lihong Pan, Anne L. Hall, Flemming Forsberg

Electronic and Electrical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Second-harmonic imaging (SecHI) has been widely used to improve the contrast of microbubbles with respect to tissue since microbubbles have a large second-harmonic response. Unlike tissue, microbubbles can also have a response at subharmonic frequency. In order to take advantage of subharmonics in contrast imaging, the image quality of subharmonic imaging (SubHI) and SecHI are analyzed through quantitative comparisons. Nonlinear tissue and bubble responses are simulated for numerical analysis. SubHI and SecHI modes are implemented on a Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA). Images of a flow phantom (ATS laboratories, CT, USA) with Sonazoid (GE Healthcare, Oslo, Norway) microbubbles are presented. The contrast-to-tissue ratio (CTR) and signal-to-noise ratio (SNR) are calculated with variations of the bubble concentration and the depth of the vessel tube. The experimental results agree well with the simulations. The CTR at the subharmonic frequency can be higher than the value in second-harmonics. For deep-lying bubbles, the CTR for SubHI is 15 dB higher than for SecHI. Although the SNR at the subharmonic frequency can be lower than that at the second-harmonic frequency, it is suggested that SubHI with high blood-to-tissue contrast may be useful when the sensitivity is a major concern.

Original language	English
Title of host publication	2011 IEEE International Ultrasonics Symposium, IUS 2011
Pages	640-643
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2011.0155
State	Published - 2011
Event	2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States Duration: 18 Oct 2011 → 21 Oct 2011

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2011 IEEE International Ultrasonics Symposium, IUS 2011
Country/Territory	United States
City	Orlando, FL
Period	18/10/11 → 21/10/11

Keywords

Contrast agent
Harmonics
Microbubble
Second-harmonic imaging
Subharmonic imaging

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10.1109/ULTSYM.2011.0155

Cite this

Park, S., Dianis, S., Thomenius, K. E., Chalek, C. L., Wayne Rigby, K., Mo, L., Lin, F., Pan, L., Hall, A. L., & Forsberg, F. (2011). Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging. In 2011 IEEE International Ultrasonics Symposium, IUS 2011 (pp. 640-643). [6293567] (IEEE International Ultrasonics Symposium, IUS). https://doi.org/10.1109/ULTSYM.2011.0155

@inproceedings{0cf2bed0b7f24531af1d531cdfa7cb4b,

title = "Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging",

abstract = "Second-harmonic imaging (SecHI) has been widely used to improve the contrast of microbubbles with respect to tissue since microbubbles have a large second-harmonic response. Unlike tissue, microbubbles can also have a response at subharmonic frequency. In order to take advantage of subharmonics in contrast imaging, the image quality of subharmonic imaging (SubHI) and SecHI are analyzed through quantitative comparisons. Nonlinear tissue and bubble responses are simulated for numerical analysis. SubHI and SecHI modes are implemented on a Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA). Images of a flow phantom (ATS laboratories, CT, USA) with Sonazoid (GE Healthcare, Oslo, Norway) microbubbles are presented. The contrast-to-tissue ratio (CTR) and signal-to-noise ratio (SNR) are calculated with variations of the bubble concentration and the depth of the vessel tube. The experimental results agree well with the simulations. The CTR at the subharmonic frequency can be higher than the value in second-harmonics. For deep-lying bubbles, the CTR for SubHI is 15 dB higher than for SecHI. Although the SNR at the subharmonic frequency can be lower than that at the second-harmonic frequency, it is suggested that SubHI with high blood-to-tissue contrast may be useful when the sensitivity is a major concern.",

keywords = "Contrast agent, Harmonics, Microbubble, Second-harmonic imaging, Subharmonic imaging",

author = "Suhyun Park and Scott Dianis and Thomenius, {Kai E.} and Chalek, {Carl L.} and {Wayne Rigby}, K. and Larry Mo and Feng Lin and Lihong Pan and Hall, {Anne L.} and Flemming Forsberg",

year = "2011",

doi = "10.1109/ULTSYM.2011.0155",

language = "English",

isbn = "9781457712531",

series = "IEEE International Ultrasonics Symposium, IUS",

pages = "640--643",

booktitle = "2011 IEEE International Ultrasonics Symposium, IUS 2011",

note = "null ; Conference date: 18-10-2011 Through 21-10-2011",

}

Park, S, Dianis, S, Thomenius, KE, Chalek, CL, Wayne Rigby, K, Mo, L, Lin, F, Pan, L, Hall, AL & Forsberg, F 2011, Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging. in 2011 IEEE International Ultrasonics Symposium, IUS 2011., 6293567, IEEE International Ultrasonics Symposium, IUS, pp. 640-643, 2011 IEEE International Ultrasonics Symposium, IUS 2011, Orlando, FL, United States, 18/10/11. https://doi.org/10.1109/ULTSYM.2011.0155

Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging. / Park, Suhyun; Dianis, Scott; Thomenius, Kai E. et al.

2011 IEEE International Ultrasonics Symposium, IUS 2011. 2011. p. 640-643 6293567 (IEEE International Ultrasonics Symposium, IUS).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

TY - GEN

T1 - Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging

AU - Park, Suhyun

AU - Dianis, Scott

AU - Thomenius, Kai E.

AU - Chalek, Carl L.

AU - Wayne Rigby, K.

AU - Mo, Larry

AU - Lin, Feng

AU - Pan, Lihong

AU - Hall, Anne L.

AU - Forsberg, Flemming

PY - 2011

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N2 - Second-harmonic imaging (SecHI) has been widely used to improve the contrast of microbubbles with respect to tissue since microbubbles have a large second-harmonic response. Unlike tissue, microbubbles can also have a response at subharmonic frequency. In order to take advantage of subharmonics in contrast imaging, the image quality of subharmonic imaging (SubHI) and SecHI are analyzed through quantitative comparisons. Nonlinear tissue and bubble responses are simulated for numerical analysis. SubHI and SecHI modes are implemented on a Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA). Images of a flow phantom (ATS laboratories, CT, USA) with Sonazoid (GE Healthcare, Oslo, Norway) microbubbles are presented. The contrast-to-tissue ratio (CTR) and signal-to-noise ratio (SNR) are calculated with variations of the bubble concentration and the depth of the vessel tube. The experimental results agree well with the simulations. The CTR at the subharmonic frequency can be higher than the value in second-harmonics. For deep-lying bubbles, the CTR for SubHI is 15 dB higher than for SecHI. Although the SNR at the subharmonic frequency can be lower than that at the second-harmonic frequency, it is suggested that SubHI with high blood-to-tissue contrast may be useful when the sensitivity is a major concern.

AB - Second-harmonic imaging (SecHI) has been widely used to improve the contrast of microbubbles with respect to tissue since microbubbles have a large second-harmonic response. Unlike tissue, microbubbles can also have a response at subharmonic frequency. In order to take advantage of subharmonics in contrast imaging, the image quality of subharmonic imaging (SubHI) and SecHI are analyzed through quantitative comparisons. Nonlinear tissue and bubble responses are simulated for numerical analysis. SubHI and SecHI modes are implemented on a Logiq 9 scanner (GE Healthcare, Milwaukee, WI, USA). Images of a flow phantom (ATS laboratories, CT, USA) with Sonazoid (GE Healthcare, Oslo, Norway) microbubbles are presented. The contrast-to-tissue ratio (CTR) and signal-to-noise ratio (SNR) are calculated with variations of the bubble concentration and the depth of the vessel tube. The experimental results agree well with the simulations. The CTR at the subharmonic frequency can be higher than the value in second-harmonics. For deep-lying bubbles, the CTR for SubHI is 15 dB higher than for SecHI. Although the SNR at the subharmonic frequency can be lower than that at the second-harmonic frequency, it is suggested that SubHI with high blood-to-tissue contrast may be useful when the sensitivity is a major concern.

KW - Contrast agent

KW - Harmonics

KW - Microbubble

KW - Second-harmonic imaging

KW - Subharmonic imaging

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U2 - 10.1109/ULTSYM.2011.0155

DO - 10.1109/ULTSYM.2011.0155

M3 - Conference contribution

AN - SCOPUS:84869008321

SN - 9781457712531

T3 - IEEE International Ultrasonics Symposium, IUS

SP - 640

EP - 643

BT - 2011 IEEE International Ultrasonics Symposium, IUS 2011

Y2 - 18 October 2011 through 21 October 2011

ER -

Quantitative analysis of subharmonic imaging using microbubbles in contrast imaging

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Keywords

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