QSAR study of quinolinediones with inhibitory activity of endothelium-dependent vasorelaxation by CoMSIA

Hea Young Park Choo; Suyoung Choi; Chung Kyu Ryu; Hwa Jung Kim; In Young Lee; Ae Nim Pae; Hun Yeong Koh

doi:10.1016/S0968-0896(03)00045-2

QSAR study of quinolinediones with inhibitory activity of endothelium-dependent vasorelaxation by CoMSIA

Hea Young Park Choo
, Suyoung Choi
, Chung Kyu Ryu
, Hwa Jung Kim
, In Young Lee
, Ae Nim Pae
, Hun Yeong Koh

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vasorelaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q² (0.741) and r² (0.960) values, gave reliability to the prediction of inhibitory activity of this series.

Original language	English
Pages (from-to)	2019-2023
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry
Volume	11
Issue number	9
DOIs	https://doi.org/10.1016/S0968-0896(03)00045-2
State	Published - 1 May 2003

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title = "QSAR study of quinolinediones with inhibitory activity of endothelium-dependent vasorelaxation by CoMSIA",

abstract = "The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vasorelaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q2 (0.741) and r2 (0.960) values, gave reliability to the prediction of inhibitory activity of this series.",

author = "Choo, \{Hea Young Park\} and Suyoung Choi and Ryu, \{Chung Kyu\} and Kim, \{Hwa Jung\} and Lee, \{In Young\} and Pae, \{Ae Nim\} and Koh, \{Hun Yeong\}",

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AU - Choo, Hea Young Park

AU - Choi, Suyoung

AU - Ryu, Chung Kyu

AU - Kim, Hwa Jung

AU - Lee, In Young

AU - Pae, Ae Nim

AU - Koh, Hun Yeong

PY - 2003/5/1

Y1 - 2003/5/1

N2 - The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vasorelaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q2 (0.741) and r2 (0.960) values, gave reliability to the prediction of inhibitory activity of this series.

AB - The 3D-QSAR study of quinolinediones which showed potent inhibitory effect on the acetylcholine induced vasorelaxation of rat aorta with the endothelium was conducted by CoMSIA. The statistical result, cross-validated q2 (0.741) and r2 (0.960) values, gave reliability to the prediction of inhibitory activity of this series.

UR - https://www.scopus.com/pages/publications/0037401606

U2 - 10.1016/S0968-0896(03)00045-2

DO - 10.1016/S0968-0896(03)00045-2

M3 - Article

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AN - SCOPUS:0037401606

SN - 0968-0896

VL - 11

SP - 2019

EP - 2023

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 9

ER -

QSAR study of quinolinediones with inhibitory activity of endothelium-dependent vasorelaxation by CoMSIA

Abstract

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