PVPylated poly(alanine) as a new thermogelling polymer

Jin Ok Han, Min Kyung Joo, Ji Hye Jang, Min Hee Park, Byeongmoon Jeong

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

In order to investigate poly(N-vinyl pyrrolidone) as an alternative to polyethylene glycol) in preparing a biomedical polymer, we synthesized a series of reverse thermogelling poly(N-vinyl pyrrolidone-b-alanine) (PVP-PA). The amphiphilic polymers consisting of the hydrophilic PVP block and the hydrophobic PA block formed micelles in water and the micelles aggregated as the temperature increased. FTIR spectroscopy, circular dichrosim spectroscopy, and 13C NMR spectroscopy showed that the aggregation behavior accompanied a change in PA conformation as well as a decrease in the molecular motion of PVP-PA. The sol-to-gel transition temperature decreased as the PA block length increased, PVP block length decreased, and L-alanine/DL-alanine ratio of PA increased. This paper suggests that PVP can be a promising alternative to poly(ethylene glycol) in designing a reverse thermogelling biomaterial.

Original languageEnglish
Pages (from-to)6710-6715
Number of pages6
JournalMacromolecules
Volume42
Issue number17
DOIs
StatePublished - 8 Sep 2009

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