Hedonia (seeking pleasure and comfort) and eudaimonia (seeking to use and develop the best in oneself) are often seen as opposing pursuits, yet each may contribute to well-being in different ways. We conducted four studies (two correlational, one experience-sampling, and one intervention study) to determine outcomes associated with activities motivated by hedonic and eudaimonic aims. Overall, results indicated that: between persons (at the trait level) and within persons (at the momentary state level), hedonic pursuits related more to positive affect and carefreeness, while eudaimonic pursuits related more to meaning; between persons, eudaimonia related more to elevating experience (awe, inspiration, and sense of connection with a greater whole); within persons, hedonia related more negatively to negative affect; between and within persons, both pursuits related equally to vitality; and both pursuits showed some links with life satisfaction, though hedonia's links were more frequent. People whose lives were high in both eudaimonia and hedonia had: higher degrees of most well-being variables than people whose lives were low in both pursuits (but did not differ in negative affect or carefreeness); higher positive affect and carefreeness than predominantly eudaimonic individuals; and higher meaning, elevating experience, and vitality than predominantly hedonic individuals. In the intervention study, hedonia produced more well-being benefits at short-term follow-up, while eudaimonia produced more at 3-month follow-up. The findings show that hedonia and eudaimonia occupy both overlapping and distinct niches within a complete picture of well-being, and their combination may be associated with the greatest well-being.