TY - JOUR
T1 - Psychological and genetic risk factors associated with suicidal behavior in Korean patients with mood disorders
AU - Choi, Hee Yeon
AU - Kim, Ga Eun
AU - Kong, Kyoung Ae
AU - Lee, Yu Jin
AU - Lim, Weon Jeong
AU - Park, So Hyun
AU - Ha, Su Hee
AU - Kim, Soo In
N1 - Publisher Copyright:
© 2018
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Introduction: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea. Methods: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404). Results: Patients in the high-SI and SA groups reported more severe depressive, hopelessness, and anxiety symptoms and lower resilience and used less social support-seeking coping than those in the non-significant SI and non-SA groups. Multivariate logistic analysis revealed that depressive disorder, depressive symptoms, poor social support, and less social support-seeking coping were significant independent predictors of suicidal ideation. After adjustment for covariates, age, alcohol consumption, and the rs4680 AA genotype in the COMT gene were associated with suicide attempt. Limitations: The modest sample size and a relatively few candidate genes are limitations of the study. In addition, there is no normal control group and the retrospective evaluation of SA limits the interpretation of the causal relationship with factors affecting SA. Conclusions: Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMT rs4680 Met/Met genotype.
AB - Introduction: To prevent suicide, a nationwide important issue in Korea, understanding its etiology is essential. This study aimed to delineate the risk factors for suicidal behavior in mood disorder patients in Korea. Methods: 216 patients with mood disorders were recruited. We measured suicidal ideation (SI) and suicide attempt (SA) history and the association of six gene polymorphisms with SB: COMT (rs4680), HTR1A (rs6295), TPH1 (rs1800532), BDNF (rs6265), SLC1A3 (rs2269272), and SLC1A2 (rs4755404). Results: Patients in the high-SI and SA groups reported more severe depressive, hopelessness, and anxiety symptoms and lower resilience and used less social support-seeking coping than those in the non-significant SI and non-SA groups. Multivariate logistic analysis revealed that depressive disorder, depressive symptoms, poor social support, and less social support-seeking coping were significant independent predictors of suicidal ideation. After adjustment for covariates, age, alcohol consumption, and the rs4680 AA genotype in the COMT gene were associated with suicide attempt. Limitations: The modest sample size and a relatively few candidate genes are limitations of the study. In addition, there is no normal control group and the retrospective evaluation of SA limits the interpretation of the causal relationship with factors affecting SA. Conclusions: Suicidal behavior in Korean patients with mood disorders may be associated with younger age, alcohol consumption, depressive symptoms, poor social support, less social support-seeking coping, and the COMT rs4680 Met/Met genotype.
KW - COMT gene
KW - Mood disorders
KW - Risk factors
KW - Single nucleotide polymorphism
KW - Suicide
KW - rs4680
UR - http://www.scopus.com/inward/record.url?scp=85045688097&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2018.04.059
DO - 10.1016/j.jad.2018.04.059
M3 - Article
C2 - 29684863
AN - SCOPUS:85045688097
SN - 0165-0327
VL - 235
SP - 489
EP - 498
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -