Pseudomonas aeruginosa bacteremia in patients with liver cirrhosis: A comparison with bacteremia caused by Enterobacteriaceae

Ji Hwan Bang, Younghee Jung, Shinhye Cheon, Chung Jong Kim, Kyung Ho Song, Pyeong Gyun Choe, Wan Beom Park, Eu Suk Kim, Sang Won Park, Hong Bin Kim, Myoung don Oh, Hyo Suk Lee, Nam Joong Kim

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Abstract

Background: This study was performed to detect risk factors for Pseudomonas aeruginosa bacteremia in patients with liver cirrhosis.Methods: A retrospective case-control study was designed to identify risk factors for P. aeruginosa bacteremia in cirrhotic patients. The cases were cirrhotic patients with P. aeruginosa bacteremia and the controls were cirrhotic patients with Enterobacteriaceae bacteremia.Results: Sixty-one cases and the same number of controls were enrolled. In a multivariate analysis, younger age {adjusted odds ratio (aOR) per one year: 0.96, 95% confidence interval: 0.93 - 0.99}, nosocomial acquisition (aOR 3.87, 95% confidence interval: 1.50 - 9.94), preexisting biliary disease (aOR 4.79, 95% confidence interval: 1.92 - 10.47), and recent exposure to immunosuppressive agent (aOR 3.10, 95% confidence interval: 1.23 - 7.82) were associated with P. aeruginosa bacteremia. In the case group the frequency of appropriate initial antibiotic regimens was considerably lower than in the control group: 29.5% vs. 65.6% (P <0.01). However, thirty day mortality did not differ significantly between cases and controls (19.7% vs. 24.6%).Conclusions: Nosocomial acquisition, preexisting biliary disease, and recent use of immunosuppressive agents are strong predictive factors for P. aeruginosa bacteremia in cirrhotic patients.

Original languageEnglish
Article number332
JournalBMC Infectious Diseases
Volume13
Issue number1
DOIs
StatePublished - 19 Jul 2013

Keywords

  • Bacteremia
  • Liver cirrhosis
  • Pseudomonas aeruginosa

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