Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

Hyun Tai Lee; Seung Won Yang; Kyeong Ho Kim; Eun Kyoung Seo; Woongchon Mar

doi:10.1007/bf02976555

Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

Hyun Tai Lee
, Seung Won Yang
, Kyeong Ho Kim
, Eun Kyoung Seo
, Woongchon Mar

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

30 Scopus citations

Abstract

Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var. chinensts. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC₅₀ value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L-N⁶-(1-iminoethyl)lysine (IC₅₀ 3.49 μM). 2,3-Dihydroaromaticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC₅₀ values of 1.05 and 0.69 μM, respectively.

Original language	English
Pages (from-to)	151-153
Number of pages	3
Journal	Archives of Pharmacal Research
Volume	25
Issue number	2
DOIs	https://doi.org/10.1007/bf02976555
State	Published - Apr 2002

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (00-CD-01-0001).

Keywords

2,3-Dihydroaromaticin
Bigelovin
Ergolide
Inula britannica var. chinensis
iNOS inhibitor

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10.1007/bf02976555

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@article{f0fe222b72984fa9bd911aad3da64e47,

title = "Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase",

abstract = "Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var. chinensts. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L-N6-(1-iminoethyl)lysine (IC50 3.49 μM). 2,3-Dihydroaromaticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 μM, respectively.",

keywords = "2,3-Dihydroaromaticin, Bigelovin, Ergolide, Inula britannica var. chinensis, iNOS inhibitor",

author = "Lee, \{Hyun Tai\} and Yang, \{Seung Won\} and Kim, \{Kyeong Ho\} and Seo, \{Eun Kyoung\} and Woongchon Mar",

note = "Funding Information: This study was supported by a grant from the Korea Health 21 R\&D Project, Ministry of Health \& Welfare, Republic of Korea (00-CD-01-0001).",

year = "2002",

month = apr,

doi = "10.1007/bf02976555",

language = "English",

volume = "25",

pages = "151--153",

journal = "Archives of Pharmacal Research",

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publisher = "Pharmaceutical Society of Korea",

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TY - JOUR

T1 - Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

AU - Lee, Hyun Tai

AU - Yang, Seung Won

AU - Kim, Kyeong Ho

AU - Seo, Eun Kyoung

AU - Mar, Woongchon

N1 - Funding Information: This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (00-CD-01-0001).

PY - 2002/4

Y1 - 2002/4

N2 - Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var. chinensts. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L-N6-(1-iminoethyl)lysine (IC50 3.49 μM). 2,3-Dihydroaromaticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 μM, respectively.

AB - Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var. chinensts. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L-N6-(1-iminoethyl)lysine (IC50 3.49 μM). 2,3-Dihydroaromaticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 μM, respectively.

KW - 2,3-Dihydroaromaticin

KW - Bigelovin

KW - Ergolide

KW - Inula britannica var. chinensis

KW - iNOS inhibitor

UR - https://www.scopus.com/pages/publications/0036545562

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DO - 10.1007/bf02976555

M3 - Article

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AN - SCOPUS:0036545562

SN - 0253-6269

VL - 25

SP - 151

EP - 153

JO - Archives of Pharmacal Research

JF - Archives of Pharmacal Research

IS - 2

ER -

Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

Abstract

Bibliographical note

Keywords

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