Pseudoguaianolides isolated from Inula britannica var. chinenis as inhibitory constituents against inducible nitric oxide synthase

Hyun Tai Lee, Seung Won Yang, Ho Kim Kyeong, Eun Kyoung Seo, Woongchon Mar

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Three pseudoguaianolide type sesquiterpenes, bigelovin (1), 2,3-dihydroaromaticin (2), and ergolide (3) were isolated as inhibitory constituents against inducible nitric oxide synthase (iNOS) from the flowers of Inula britannica var. chinensis. Bigelovin (1) exhibited a highly potent inhibitory activity on lipopolysaccharide (LPS)-induced iNOS in murine macrophage RAW 264.7 cells with an IC50 value of 0.46 mM, which is about 8 times more potent than the known selective inhibitor of iNOS, L- N 6-(1-iminoethyl)lysine (IC50 3.49 μM). 2,3-Dihydroaromaticin (2) and ergolide (3) also exhibited potent inhibitory activities on LPS-induced iNOS with IC50 values of 1.05 and 0.69 μM, respectively.

Original languageEnglish
Pages (from-to)151-153
Number of pages3
JournalArchives of Pharmacal Research
Volume25
Issue number2
DOIs
StatePublished - 30 Apr 2002

Bibliographical note

Funding Information:
This study was supported by a grant from the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (00-CD-01-0001).

Keywords

  • 2,3-Dihydroaromaticin
  • Bigelovin
  • Ergolide
  • iNOS inhibitor
  • Inula britannica var. chinensis

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