@article{214266c9d06a41379a2c9e816cb0da81,
title = "Proteogenomic Characterization of Human Early-Onset Gastric Cancer",
abstract = "We report proteogenomic analysis of diffuse gastric cancers (GCs) in young populations. Phosphoproteome data elucidated signaling pathways associated with somatic mutations based on mutation-phosphorylation correlations. Moreover, correlations between mRNA and protein abundances provided potential oncogenes and tumor suppressors associated with patient survival. Furthermore, integrated clustering of mRNA, protein, phosphorylation, and N-glycosylation data identified four subtypes of diffuse GCs. Distinguishing these subtypes was possible by proteomic data. Four subtypes were associated with proliferation, immune response, metabolism, and invasion, respectively; and associations of the subtypes with immune- and invasion-related pathways were identified mainly by phosphorylation and N-glycosylation data. Therefore, our proteogenomic analysis provides additional information beyond genomic analyses, which can improve understanding of cancer biology and patient stratification in diffuse GCs.",
keywords = "cancer subtypes, correlation between mRNA and protein abundance changes, correlation between mutation and phosphorylation, diffuse gastric cancer, proteogenomics, somatic nonsynonymous mutations",
author = "Mun, {Dong Gi} and Jinhyuk Bhin and Sangok Kim and Hyunwoo Kim and Jung, {Jae Hun} and Yeonjoo Jung and Jang, {Ye Eun} and Park, {Jong Moon} and Hokeun Kim and Yeonhwa Jung and Hangyeore Lee and Jingi Bae and Seunghoon Back and Kim, {Su Jin} and Jieun Kim and Heejin Park and Honglan Li and Hwang, {Kyu Baek} and Park, {Young Soo} and Yook, {Jeong Hwan} and Kim, {Byung Sik} and Kwon, {Sun Young} and Ryu, {Seung Wan} and Park, {Do Youn} and Jeon, {Tae Yong} and Kim, {Dae Hwan} and Lee, {Jae Hyuck} and Han, {Sang Uk} and Song, {Kyu Sang} and Dongmin Park and Park, {Jun Won} and Henry Rodriguez and Jaesang Kim and Hookeun Lee and Kim, {Kwang Pyo} and Yang, {Eun Gyeong} and Kim, {Hark Kyun} and Eunok Paek and Sanghyuk Lee and Lee, {Sang Won} and Daehee Hwang",
note = "Funding Information: We thank Dr. Douglas Lowy at U.S. National Cancer Institute for critical comments. This work was supported by grants from the Collaborative Genome Program for Fostering New Post-Genome Industry (2012M3A9B9028156 and NRF-2017M3C9A5031397) and Institute for Basic Science (IBS-R013-A1) funded by the Korean Ministry of Science and ICT (MSIT). This work was done under the auspices of the Memorandum of Understanding between the Korea Institute of Science and Technology (KIST) and the U.S. National Cancer Institute's Office of Cancer Clinical Proteomics Research (Clinical Proteomic Tumor Analysis Consortium program––CPTAC). For providing the samples, we thank the members of the National Biobank of Korea (Asan Bio-Resource Center, Keimyung Human Bio-Resource Bank, Biobank of Pusan National University, Biobank of Chonnam National University Hwasun Hospital, Biobank of Chungnam National University Hospital, and Ajou Human Bio-Resource Bank) supported by the Korean Ministry of Health and Welfare. Funding Information: We thank Dr. Douglas Lowy at U.S. National Cancer Institute for critical comments. This work was supported by grants from the Collaborative Genome Program for Fostering New Post-Genome Industry ( 2012M3A9B9028156 and NRF-2017M3C9A5031397 ) and Institute for Basic Science ( IBS-R013-A1 ) funded by the Korean Ministry of Science and ICT (MSIT). This work was done under the auspices of the Memorandum of Understanding between the Korea Institute of Science and Technology (KIST) and the U.S. National Cancer Institute's Office of Cancer Clinical Proteomics Research (Clinical Proteomic Tumor Analysis Consortium program––CPTAC). For providing the samples, we thank the members of the National Biobank of Korea (Asan Bio-Resource Center, Keimyung Human Bio-Resource Bank, Biobank of Pusan National University, Biobank of Chonnam National University Hwasun Hospital, Biobank of Chungnam National University Hospital, and Ajou Human Bio-Resource Bank) supported by the Korean Ministry of Health and Welfare . Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",
year = "2019",
month = jan,
day = "14",
doi = "10.1016/j.ccell.2018.12.003",
language = "English",
volume = "35",
pages = "111--124.e10",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "1",
}