Abstract
PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.
Original language | English |
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Pages (from-to) | 6436-6441 |
Number of pages | 6 |
Journal | Advanced Materials |
Volume | 26 |
Issue number | 37 |
DOIs | |
State | Published - 1 Oct 2014 |
Bibliographical note
Publisher Copyright:© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords
- core/shell
- gold nanoparticle
- nanotoxicity
- photothermal therapy
- proteinticle