Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

Koo Chul Kwon; Ju Hee Ryu; Jong Hwan Lee; Eun Jung Lee; Ick Chan Kwon; Kwangmeyung Kim; Jeewon Lee

doi:10.1002/adma.201401499

Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

Koo Chul Kwon, Ju Hee Ryu, Jong Hwan Lee, Eun Jung Lee, Ick Chan Kwon, Kwangmeyung Kim, Jeewon Lee

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.

Original language	English
Pages (from-to)	6436-6441
Number of pages	6
Journal	Advanced Materials
Volume	26
Issue number	37
DOIs	https://doi.org/10.1002/adma.201401499
State	Published - 1 Oct 2014

Bibliographical note

Publisher Copyright:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Keywords

core/shell
gold nanoparticle
nanotoxicity
photothermal therapy
proteinticle

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/adma.201401499

Cite this

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title = "Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity",

abstract = "PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.",

keywords = "core/shell, gold nanoparticle, nanotoxicity, photothermal therapy, proteinticle",

author = "Kwon, {Koo Chul} and Ryu, {Ju Hee} and Lee, {Jong Hwan} and Lee, {Eun Jung} and Kwon, {Ick Chan} and Kwangmeyung Kim and Jeewon Lee",

note = "Publisher Copyright: {\textcopyright} 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2014",

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doi = "10.1002/adma.201401499",

language = "English",

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TY - JOUR

T1 - Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

AU - Kwon, Koo Chul

AU - Ryu, Ju Hee

AU - Lee, Jong Hwan

AU - Lee, Eun Jung

AU - Kwon, Ick Chan

AU - Kim, Kwangmeyung

AU - Lee, Jeewon

PY - 2014/10/1

Y1 - 2014/10/1

N2 - PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.

AB - PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.

KW - core/shell

KW - gold nanoparticle

KW - nanotoxicity

KW - photothermal therapy

KW - proteinticle

UR - http://www.scopus.com/inward/record.url?scp=84908066591&partnerID=8YFLogxK

U2 - 10.1002/adma.201401499

DO - 10.1002/adma.201401499

M3 - Article

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AN - SCOPUS:84908066591

SN - 0935-9648

VL - 26

SP - 6436

EP - 6441

JO - Advanced Materials

JF - Advanced Materials

IS - 37

ER -

Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

Abstract

Bibliographical note

Keywords

UN SDGs

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