PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.
Bibliographical noteFunding Information:
This study was supported by the 2012 NLRL (National Leading Research Lab.) Project (grant no. 2012R1A2A1A01008085) (the main project that supported this work), the Basic Science Research Program (ERC program, grant no. 2010-0029409) of the National Research Foundation of Korea (NRF), and KIST Intramural project (Theragnosis). The Korea Institute of Science and Technology Animal Ethics Committee approved the use of animals in this study (2009-01-5255-007), and all animal experimental procedures were in compliance with the institutional guidelines of Korea Institute of Science and Technology and the relevant laws.
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- gold nanoparticle
- photothermal therapy