Proteinticle/Gold Core/Shell Nanoparticles for Targeted Cancer Therapy without Nanotoxicity

Koo Chul Kwon, Ju Hee Ryu, Jong Hwan Lee, Eun Jung Lee, Ick Chan Kwon, Kwangmeyung Kim, Jeewon Lee

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


PGCS-NPs (40 nm) with excellent photothermal activity are developed, on the surface of which affibody peptides with specific affinity for EGFR and many small gold dots (1-3 nm) are densely presented. The IV-injected PGCS-NPs into EGFR-expressing tumor-bearing mice successfully perform targeted and photothermal therapy of cancer. It seems that the small gold dots released from disassembled PGCS-NPs are easily removed and never cause in vivo toxicity problems.

Original languageEnglish
Pages (from-to)6436-6441
Number of pages6
JournalAdvanced Materials
Issue number37
StatePublished - 1 Oct 2014

Bibliographical note

Publisher Copyright:
© 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.


  • core/shell
  • gold nanoparticle
  • nanotoxicity
  • photothermal therapy
  • proteinticle


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