Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells

Jong Ho Kim; Seulki Lee; Kyeongsoon Park; Yun Nam Hae; Young Jang Soon; Inchan Youn; Kwangmeyung Kim; Hyesung Jeon; Rang Woon Park; In San Kim; Kuiwon Choi; Chan Kwon Ick

doi:10.1002/anie.200700767

Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells

Jong Ho Kim, Seulki Lee, Kyeongsoon Park, Yun Nam Hae, Young Jang Soon, Inchan Youn, Kwangmeyung Kim, Hyesung Jeon, Rang Woon Park, In San Kim, Kuiwon Choi, Chan Kwon Ick

Department of Pharmaceutical Sciences

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

(Figure Presented) Take your PIC: Cell-permeable and biocompatible polyion-induced complex (PIC) nanoparticles were developed consisting of a negatively charged polymer along with a positively charged polymer conjugated to a near-infrared fluorophore and a protein-kinase-specific peptide. Owing to profound changes in fluorescence, the PIC nanoparticle is an attractive probe for protein kinase A (PKA) in single living cells. ATP = adenosine triphosphate, ADP = adenosine diphosphate.

Original language	English
Pages (from-to)	5779-5782
Number of pages	4
Journal	Angewandte Chemie - International Edition
Volume	46
Issue number	30
DOIs	https://doi.org/10.1002/anie.200700767
State	Published - 2007

Keywords

Cell imaging
Fluorescent probes
Nanoparticles
Protein kinases
Sensors

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title = "Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells",

abstract = "(Figure Presented) Take your PIC: Cell-permeable and biocompatible polyion-induced complex (PIC) nanoparticles were developed consisting of a negatively charged polymer along with a positively charged polymer conjugated to a near-infrared fluorophore and a protein-kinase-specific peptide. Owing to profound changes in fluorescence, the PIC nanoparticle is an attractive probe for protein kinase A (PKA) in single living cells. ATP = adenosine triphosphate, ADP = adenosine diphosphate.",

keywords = "Cell imaging, Fluorescent probes, Nanoparticles, Protein kinases, Sensors",

author = "Kim, {Jong Ho} and Seulki Lee and Kyeongsoon Park and Hae, {Yun Nam} and Soon, {Young Jang} and Inchan Youn and Kwangmeyung Kim and Hyesung Jeon and Park, {Rang Woon} and Kim, {In San} and Kuiwon Choi and Ick, {Chan Kwon}",

year = "2007",

doi = "10.1002/anie.200700767",

language = "English",

volume = "46",

pages = "5779--5782",

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TY - JOUR

T1 - Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells

AU - Kim, Jong Ho

AU - Lee, Seulki

AU - Park, Kyeongsoon

AU - Hae, Yun Nam

AU - Soon, Young Jang

AU - Youn, Inchan

AU - Kim, Kwangmeyung

AU - Jeon, Hyesung

AU - Park, Rang Woon

AU - Kim, In San

AU - Choi, Kuiwon

AU - Ick, Chan Kwon

PY - 2007

Y1 - 2007

N2 - (Figure Presented) Take your PIC: Cell-permeable and biocompatible polyion-induced complex (PIC) nanoparticles were developed consisting of a negatively charged polymer along with a positively charged polymer conjugated to a near-infrared fluorophore and a protein-kinase-specific peptide. Owing to profound changes in fluorescence, the PIC nanoparticle is an attractive probe for protein kinase A (PKA) in single living cells. ATP = adenosine triphosphate, ADP = adenosine diphosphate.

AB - (Figure Presented) Take your PIC: Cell-permeable and biocompatible polyion-induced complex (PIC) nanoparticles were developed consisting of a negatively charged polymer along with a positively charged polymer conjugated to a near-infrared fluorophore and a protein-kinase-specific peptide. Owing to profound changes in fluorescence, the PIC nanoparticle is an attractive probe for protein kinase A (PKA) in single living cells. ATP = adenosine triphosphate, ADP = adenosine diphosphate.

KW - Cell imaging

KW - Fluorescent probes

KW - Nanoparticles

KW - Protein kinases

KW - Sensors

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DO - 10.1002/anie.200700767

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SN - 1433-7851

VL - 46

SP - 5779

EP - 5782

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 30

ER -

Protein-phosphorylation-responsive polymeric nanoparticles for imaging protein kinase activities in single living cells

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Keywords

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