Protein nanocapsule weaved with enzymatically degradable polymerie network

Zhen Gu, Ming Yan, Biliang Hu, Kye Ll Joo, Anuradha Biswas, Yu Huang, Yunfeng Lu, Pin Wang, Yi Tang

Research output: Contribution to journalArticlepeer-review

120 Scopus citations

Abstract

Target proteins can be functionally encapsulated using a cocoon-like polymeric nanocapsule formed by interfacial polymerization. The nanocapsule is cross-linked by peptides that can be proteolyzed by proteases upon which the protein cargo is released. The proteasemediated degradation process can be controlled in a spatiotemporal fashion through modification of the peptide cross-linker with photolabile moieties. We demonstrate the utility of this approach through the cytoplasmic delivery of the apoptosis inducing caspase-3 to cancer cells.

Original languageEnglish
Pages (from-to)4533-4538
Number of pages6
JournalNano Letters
Volume9
Issue number12
DOIs
StatePublished - 9 Dec 2009

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