Abstract
Target proteins can be functionally encapsulated using a cocoon-like polymeric nanocapsule formed by interfacial polymerization. The nanocapsule is cross-linked by peptides that can be proteolyzed by proteases upon which the protein cargo is released. The proteasemediated degradation process can be controlled in a spatiotemporal fashion through modification of the peptide cross-linker with photolabile moieties. We demonstrate the utility of this approach through the cytoplasmic delivery of the apoptosis inducing caspase-3 to cancer cells.
Original language | English |
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Pages (from-to) | 4533-4538 |
Number of pages | 6 |
Journal | Nano Letters |
Volume | 9 |
Issue number | 12 |
DOIs | |
State | Published - 9 Dec 2009 |