TY - JOUR
T1 - Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen
T2 - A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy
AU - Cheng, Hong Bo
AU - Qiao, Bin
AU - Li, Hao
AU - Cao, Jin
AU - Luo, Yuanli
AU - Kotraiah Swamy, Kunemadihalli Mathada
AU - Zhao, Jing
AU - Wang, Zhigang
AU - Lee, Jin Yong
AU - Liang, Xing Jie
AU - Yoon, Juyoung
N1 - Funding Information:
This work was supported by Fundamental Research Funds for the Central Universities (11170042105, buctrc202004), National Natural Science Foundation of China (21502195), Natural Science Foundation key project (31630027 and 32030060), NSFC international collaboration key project (grant No. 51861135103) and NSFC-DFG project (31761133013). The authors also appreciate the support by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDA09030301). The authors are sincerely grateful for financial support from the Natural Science Foundation Project (31630026), Special Key Project of Technological Innovation, and Application Development in Chongqing (cstc2019jscx-dxwtBX0004). J.Y. was supported by a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No.2012R1A3A2048814).
Publisher Copyright:
© 2021 American Chemical Society.
PY - 2021/2/10
Y1 - 2021/2/10
N2 - The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.
AB - The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.
UR - http://www.scopus.com/inward/record.url?scp=85100667776&partnerID=8YFLogxK
U2 - 10.1021/jacs.0c12851
DO - 10.1021/jacs.0c12851
M3 - Article
C2 - 33507066
AN - SCOPUS:85100667776
SN - 0002-7863
VL - 143
SP - 2413
EP - 2422
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 5
ER -