Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy

Hong Bo Cheng, Bin Qiao, Hao Li, Jin Cao, Yuanli Luo, Kunemadihalli Mathada Kotraiah Swamy, Jing Zhao, Zhigang Wang, Jin Yong Lee, Xing Jie Liang, Juyoung Yoon

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.

Original languageEnglish
Pages (from-to)2413-2422
Number of pages10
JournalJournal of the American Chemical Society
Volume143
Issue number5
DOIs
StatePublished - 10 Feb 2021

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