Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy

Hong Bo Cheng; Bin Qiao; Hao Li; Jin Cao; Yuanli Luo; Kunemadihalli Mathada Kotraiah Swamy; Jing Zhao; Zhigang Wang; Jin Yong Lee; Xing Jie Liang; Juyoung Yoon

doi:10.1021/jacs.0c12851

Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy

Hong Bo Cheng, Bin Qiao, Hao Li, Jin Cao, Yuanli Luo, Kunemadihalli Mathada Kotraiah Swamy, Jing Zhao, Zhigang Wang, Jin Yong Lee, Xing Jie Liang, Juyoung Yoon

Department of Chemistry & Nanoscience

Research output: Contribution to journal › Article › peer-review

78 Scopus citations

Abstract

The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.

Original language	English
Pages (from-to)	2413-2422
Number of pages	10
Journal	Journal of the American Chemical Society
Volume	143
Issue number	5
DOIs	https://doi.org/10.1021/jacs.0c12851
State	Published - 10 Feb 2021

Bibliographical note

Funding Information:
This work was supported by Fundamental Research Funds for the Central Universities (11170042105, buctrc202004), National Natural Science Foundation of China (21502195), Natural Science Foundation key project (31630027 and 32030060), NSFC international collaboration key project (grant No. 51861135103) and NSFC-DFG project (31761133013). The authors also appreciate the support by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDA09030301). The authors are sincerely grateful for financial support from the Natural Science Foundation Project (31630026), Special Key Project of Technological Innovation, and Application Development in Chongqing (cstc2019jscx-dxwtBX0004). J.Y. was supported by a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No.2012R1A3A2048814).

Publisher Copyright:
© 2021 American Chemical Society.

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10.1021/jacs.0c12851

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Cheng, H. B., Qiao, B., Li, H., Cao, J., Luo, Y., Kotraiah Swamy, K. M., Zhao, J., Wang, Z., Lee, J. Y., Liang, X. J., & Yoon, J. (2021). Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy. Journal of the American Chemical Society, 143(5), 2413-2422. https://doi.org/10.1021/jacs.0c12851

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title = "Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy",

abstract = "The development of activatable photosensitizers to allow for the reversible control of singlet oxygen (1O2) production for photodynamic therapy (PDT) faces great challenges. Fortunately, the flourishing field of supramolecular biotechnology provides more effective strategies for activatable PDT systems. Here, we developed a new reversible PDT on a switch that controls the 1O2 generation of self-assembled albumin nanotheranostics in vitro and in vivo. A new molecular design principle of aggregation-induced self-quenching photochromism and albumin on-photoswitching was demonstrated using a new asymmetric, synthetic diarylethene moiety DIA. The photosensitizer porphyrin and DIA were incorporated as building blocks in a glutaraldehyde-induced covalent albumin cross-linking nanoplatform, HSA-DIA-porphyrin nanoparticles (NPs). More importantly, the excellent photoswitching property of DIA enables the resultant nanoplatform to act as a facile, switchable strategy for photodynamic-immunotherapy.",

author = "Cheng, {Hong Bo} and Bin Qiao and Hao Li and Jin Cao and Yuanli Luo and {Kotraiah Swamy}, {Kunemadihalli Mathada} and Jing Zhao and Zhigang Wang and Lee, {Jin Yong} and Liang, {Xing Jie} and Juyoung Yoon",

note = "Funding Information: This work was supported by Fundamental Research Funds for the Central Universities (11170042105, buctrc202004), National Natural Science Foundation of China (21502195), Natural Science Foundation key project (31630027 and 32030060), NSFC international collaboration key project (grant No. 51861135103) and NSFC-DFG project (31761133013). The authors also appreciate the support by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDA09030301). The authors are sincerely grateful for financial support from the Natural Science Foundation Project (31630026), Special Key Project of Technological Innovation, and Application Development in Chongqing (cstc2019jscx-dxwtBX0004). J.Y. was supported by a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No.2012R1A3A2048814). Publisher Copyright: {\textcopyright} 2021 American Chemical Society.",

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Cheng, HB, Qiao, B, Li, H, Cao, J, Luo, Y, Kotraiah Swamy, KM, Zhao, J, Wang, Z, Lee, JY, Liang, XJ & Yoon, J 2021, 'Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy', Journal of the American Chemical Society, vol. 143, no. 5, pp. 2413-2422. https://doi.org/10.1021/jacs.0c12851

Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy. / Cheng, Hong Bo; Qiao, Bin; Li, Hao et al.
In: Journal of the American Chemical Society, Vol. 143, No. 5, 10.02.2021, p. 2413-2422.

Research output: Contribution to journal › Article › peer-review

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AU - Li, Hao

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AU - Wang, Zhigang

AU - Lee, Jin Yong

AU - Liang, Xing Jie

AU - Yoon, Juyoung

N1 - Funding Information: This work was supported by Fundamental Research Funds for the Central Universities (11170042105, buctrc202004), National Natural Science Foundation of China (21502195), Natural Science Foundation key project (31630027 and 32030060), NSFC international collaboration key project (grant No. 51861135103) and NSFC-DFG project (31761133013). The authors also appreciate the support by the “Strategic Priority Research Program” of the Chinese Academy of Sciences (Grant No. XDA09030301). The authors are sincerely grateful for financial support from the Natural Science Foundation Project (31630026), Special Key Project of Technological Innovation, and Application Development in Chongqing (cstc2019jscx-dxwtBX0004). J.Y. was supported by a grant from the National Creative Research Initiative programs of the National Research Foundation of Korea (NRF) funded by the Korean government (MSIP) (No.2012R1A3A2048814). Publisher Copyright: © 2021 American Chemical Society.

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Protein-Activatable Diarylethene Monomer as a Smart Trigger of Noninvasive Control over Reversible Generation of Singlet Oxygen: A Facile, Switchable, Theranostic Strategy for Photodynamic-Immunotherapy

Abstract

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