Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

Kyoung Ah Kang; Rui Zhang; Mei Jing Piao; Dong Ok Ko; Zhi Hong Wang; Bum Joon Kim; Jae Woo Park; Hee Sun Kim; Dong Hyun Kim; Jin Won Hyun

doi:10.1016/j.bmc.2007.10.085

Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

Kyoung Ah Kang, Rui Zhang, Mei Jing Piao, Dong Ok Ko, Zhi Hong Wang, Bum Joon Kim, Jae Woo Park, Hee Sun Kim, Dong Hyun Kim, Jin Won Hyun

Department of Molecular Medicine

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

The protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H₂O₂) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H₂O₂ via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone.

Original language	English
Pages (from-to)	1133-1141
Number of pages	9
Journal	Bioorganic and Medicinal Chemistry
Volume	16
Issue number	3
DOIs	https://doi.org/10.1016/j.bmc.2007.10.085
State	Published - 1 Feb 2008

Keywords

Extracellular signal regulated kinase
Irisolidone
Oxidative stress
Reactive oxygen species

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10.1016/j.bmc.2007.10.085

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@article{37b1ba8c4e6f4c1eafc544a25870b1cb,

title = "Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect",

abstract = "The protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H2O2) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H2O2 via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone.",

keywords = "Extracellular signal regulated kinase, Irisolidone, Oxidative stress, Reactive oxygen species",

author = "Kang, {Kyoung Ah} and Rui Zhang and Piao, {Mei Jing} and Ko, {Dong Ok} and Wang, {Zhi Hong} and Kim, {Bum Joon} and Park, {Jae Woo} and Kim, {Hee Sun} and Kim, {Dong Hyun} and Hyun, {Jin Won}",

note = "Funding Information: This research was supported by the study of the DNA repair regulation with the disease program and by the program of Basic Atomic Energy Research Institute (BAERI) which is a part of the Nuclear R&D programs grant from the Ministry of Science and Technology of Korea.",

year = "2008",

month = feb,

day = "1",

doi = "10.1016/j.bmc.2007.10.085",

language = "English",

volume = "16",

pages = "1133--1141",

journal = "Bioorganic and Medicinal Chemistry",

issn = "0968-0896",

publisher = "Elsevier Ltd.",

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T1 - Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

AU - Kang, Kyoung Ah

AU - Zhang, Rui

AU - Piao, Mei Jing

AU - Ko, Dong Ok

AU - Wang, Zhi Hong

AU - Kim, Bum Joon

AU - Park, Jae Woo

AU - Kim, Hee Sun

AU - Kim, Dong Hyun

AU - Hyun, Jin Won

N1 - Funding Information: This research was supported by the study of the DNA repair regulation with the disease program and by the program of Basic Atomic Energy Research Institute (BAERI) which is a part of the Nuclear R&D programs grant from the Ministry of Science and Technology of Korea.

PY - 2008/2/1

Y1 - 2008/2/1

N2 - The protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H2O2) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H2O2 via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone.

AB - The protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H2O2) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H2O2 via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone.

KW - Extracellular signal regulated kinase

KW - Irisolidone

KW - Oxidative stress

KW - Reactive oxygen species

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U2 - 10.1016/j.bmc.2007.10.085

DO - 10.1016/j.bmc.2007.10.085

M3 - Article

C2 - 17996449

AN - SCOPUS:38849204284

SN - 0968-0896

VL - 16

SP - 1133

EP - 1141

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 3

ER -

Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

Abstract

Keywords

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