Protective effect of irisolidone, a metabolite of kakkalide, against hydrogen peroxide induced cell damage via antioxidant effect

Kyoung Ah Kang, Rui Zhang, Mei Jing Piao, Dong Ok Ko, Zhi Hong Wang, Bum Joon Kim, Jae Woo Park, Hee Sun Kim, Dong Hyun Kim, Jin Won Hyun

Research output: Contribution to journalArticlepeer-review

38 Scopus citations

Abstract

The protective properties of irisolidone (a metabolite of kakkalide by intestinal bacteria) against hydrogen peroxide (H2O2) induced cell damage were investigated. Irisolidone was found to scavenge 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and the intracellular reactive oxygen species (ROS), thereby preventing lipid peroxidation and DNA damage. Irisolidone inhibited apoptosis in Chinese hamster lung fibroblast (V79-4) cells induced by H2O2 via radical scavenging activity. This was achieved by the activation of the extracellular signal regulated kinase (ERK) and DNA binding activity of activator protein-1 (AP-1) (a downstream transcription factor of ERK) by irisolidone.

Original languageEnglish
Pages (from-to)1133-1141
Number of pages9
JournalBioorganic and Medicinal Chemistry
Volume16
Issue number3
DOIs
StatePublished - 1 Feb 2008

Keywords

  • Extracellular signal regulated kinase
  • Irisolidone
  • Oxidative stress
  • Reactive oxygen species

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