Prospects of Marine Sterols against Pathobiology of Alzheimer's Disease: Pharmacological Insights and Technological Advances

Md Ataur Rahman, Raju Dash, Abdullah Al Mamun Sohag, Mahboob Alam, Hyewhon Rhim, Hunjoo Ha, Il Soo Moon, Md Jamal Uddin, Md Abdul Hannan

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations

Abstract

Alzheimer's disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer's agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesis. Marine sterols have been investigated for several health benefits, including anti-cancer, anti-obesity, anti-diabetes, anti-aging, and anti-Alzheimer's activities, owing to their anti-inflammatory and antioxidant properties. Marine sterols interact with various proteins and enzymes participating via diverse cellular systems such as apoptosis, the antioxidant defense system, immune response, and cholesterol homeostasis. Here, we briefly overview the potential of marine sterols against the pathology of AD and provide an insight into their pharmacological mechanisms. We also highlight technological advances that may lead to the potential application of marine sterols in the prevention and therapy of AD.

Original languageEnglish
JournalMarine Drugs
Volume19
Issue number3
DOIs
StatePublished - 20 Mar 2021

Keywords

  • cholesterol homeostasis
  • fucosterol
  • inflammation
  • marine steroids
  • neurodegeneration
  • oxidative stress

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