Prospects of Marine Sterols against Pathobiology of Alzheimer’s Disease: Pharmacological Insights and Technological Advances

Md Ataur Rahman, Raju Dash, Abdullah Al Mamun Sohag, Mahboob Alam, Hyewhon Rhim, Hunjoo Ha, Il Soo Moon, Md Jamal Uddin, Md Abdul Hannan

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations

Abstract

Alzheimer’s disease (AD) is a degenerative brain disorder characterized by a progressive decline in memory and cognition, mostly affecting the elderly. Numerous functional bioactives have been reported in marine organisms, and anti-Alzheimer’s agents derived from marine resources have gained attention as a promising approach to treat AD pathogenesis. Marine sterols have been investigated for several health benefits, including anti-cancer, anti-obesity, anti-diabetes, anti-aging, and anti-Alzheimer’s activities, owing to their anti-inflammatory and antioxidant properties. Marine sterols interact with various proteins and enzymes participating via diverse cellular systems such as apoptosis, the antioxidant defense system, immune response, and cholesterol homeostasis. Here, we briefly overview the potential of marine sterols against the pathology of AD and provide an insight into their pharmacological mechanisms. We also highlight technological advances that may lead to the potential application of marine sterols in the prevention and therapy of AD.

Original languageEnglish
Article number167
JournalMarine Drugs
Volume19
Issue number3
DOIs
StatePublished - Mar 2021

Bibliographical note

Funding Information:
I.S.M., M.A.H. and M.A.R. wish to acknowledge the National Research Foundation fellowship and grant (2018R1A2B6002232 to I.S.M., 2018H1D3A1A01074712 to M.A.H. and 2016H1D3A1908615 to M.A.R.) funded by the Ministry of Science, ICT and Future Planning. M.J.U. acknowledges National Research Foundation (No. 2020R1I1A1A01072879), and Brain Pool program funded by the Ministry of Science and ICT through the National Research Foundation (No. 2020H1D3A2A02110924), Korea.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Keywords

  • cholesterol homeostasis
  • fucosterol
  • inflammation
  • marine steroids
  • neurodegeneration
  • oxidative stress

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