Progressive lung involvement during steroid therapy in idiopathic hypereosinophilic syndrome

Ji Young Park; Ju Young Choi; Jung Ji Min; Yun Su Sim; Gun Woo Pyun; Youn Ju Na; Min Jung Kang; In Sook Kang; Si Nae Lee; Yookyung Kim; Jee Hyong Jeong; Jin Hwa Lee; Eun Mee Cheon; Jung-Hyun Chang

doi:10.4046/trd.2005.59.1.97

Progressive lung involvement during steroid therapy in idiopathic hypereosinophilic syndrome

Ji Young Park, Ju Young Choi, Jung Ji Min, Yun Su Sim, Gun Woo Pyun, Youn Ju Na, Min Jung Kang, In Sook Kang, Si Nae Lee, Yookyung Kim, Jee Hyong Jeong, Jin Hwa Lee, Eun Mee Cheon, Jung-Hyun Chang

Research output: Contribution to journal › Article › peer-review

Abstract

Hypereosinophilic syndrome (HES) is characterized by a sustained eosinophilia of 1,500/mm³ or more in the absence of any known causes or the signs and symptoms of organ involvement. We report a 64-year-old man with HES initially presenting with involvement of the liver and bone marrow. Despite controlling the eosinophilia by corticosteroid, he developed a cerebral infarction and later progressive interstitial pneumonia. Brain angiography revealed a severe stenosis of the proximal right internal carotid artery (ICA) and a complete obstruction of the intracranial ICA. An open lung biopsy revealed fibrosis and lymphoplasma cell infiltration without eosinophils, which were consistent with nonspecific interstitial pneumonia.

Original language	English
Pages (from-to)	97-103
Number of pages	7
Journal	Tuberculosis and Respiratory Diseases
Volume	59
Issue number	1
DOIs	https://doi.org/10.4046/trd.2005.59.1.97
State	Published - Jul 2005

Keywords

Idiopathic hypereosinphilic syndrome

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10.4046/trd.2005.59.1.97

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Park, J. Y., Choi, J. Y., Min, J. J., Sim, Y. S., Pyun, G. W., Na, Y. J., Kang, M. J., Kang, I. S., Lee, S. N., Kim, Y., Jeong, J. H., Lee, J. H., Cheon, E. M., & Chang, J.-H. (2005). Progressive lung involvement during steroid therapy in idiopathic hypereosinophilic syndrome. Tuberculosis and Respiratory Diseases, 59(1), 97-103. https://doi.org/10.4046/trd.2005.59.1.97

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abstract = "Hypereosinophilic syndrome (HES) is characterized by a sustained eosinophilia of 1,500/mm3 or more in the absence of any known causes or the signs and symptoms of organ involvement. We report a 64-year-old man with HES initially presenting with involvement of the liver and bone marrow. Despite controlling the eosinophilia by corticosteroid, he developed a cerebral infarction and later progressive interstitial pneumonia. Brain angiography revealed a severe stenosis of the proximal right internal carotid artery (ICA) and a complete obstruction of the intracranial ICA. An open lung biopsy revealed fibrosis and lymphoplasma cell infiltration without eosinophils, which were consistent with nonspecific interstitial pneumonia.",

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doi = "10.4046/trd.2005.59.1.97",

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AU - Park, Ji Young

AU - Choi, Ju Young

AU - Min, Jung Ji

AU - Sim, Yun Su

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AU - Na, Youn Ju

AU - Kang, Min Jung

AU - Kang, In Sook

AU - Lee, Si Nae

AU - Kim, Yookyung

AU - Jeong, Jee Hyong

AU - Lee, Jin Hwa

AU - Cheon, Eun Mee

AU - Chang, Jung-Hyun

PY - 2005/7

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N2 - Hypereosinophilic syndrome (HES) is characterized by a sustained eosinophilia of 1,500/mm3 or more in the absence of any known causes or the signs and symptoms of organ involvement. We report a 64-year-old man with HES initially presenting with involvement of the liver and bone marrow. Despite controlling the eosinophilia by corticosteroid, he developed a cerebral infarction and later progressive interstitial pneumonia. Brain angiography revealed a severe stenosis of the proximal right internal carotid artery (ICA) and a complete obstruction of the intracranial ICA. An open lung biopsy revealed fibrosis and lymphoplasma cell infiltration without eosinophils, which were consistent with nonspecific interstitial pneumonia.

AB - Hypereosinophilic syndrome (HES) is characterized by a sustained eosinophilia of 1,500/mm3 or more in the absence of any known causes or the signs and symptoms of organ involvement. We report a 64-year-old man with HES initially presenting with involvement of the liver and bone marrow. Despite controlling the eosinophilia by corticosteroid, he developed a cerebral infarction and later progressive interstitial pneumonia. Brain angiography revealed a severe stenosis of the proximal right internal carotid artery (ICA) and a complete obstruction of the intracranial ICA. An open lung biopsy revealed fibrosis and lymphoplasma cell infiltration without eosinophils, which were consistent with nonspecific interstitial pneumonia.

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Progressive lung involvement during steroid therapy in idiopathic hypereosinophilic syndrome

Abstract

Keywords

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