Progress toward a group B streptococcal vaccine

Joon Young Song, Jae Hyang Lim, Sangyong Lim, Zhi Yong, Ho Seong Seo

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations

Abstract

Streptococcus agalactiae (group B Streptococcus, GBS) is a leading cause of severe invasive disease in neonate, elderly, and immunocompromised patients worldwide. Despite recent advances in the diagnosis and intrapartum antibiotic prophylaxis (IAP) of GBS infections, it remains one of the most common causes of neonatal morbidity and mortality, causing serious infections. Furthermore, recent studies reported an increasing number of GBS infections in pregnant women and elderly. Although IAP is effective, it has several limitations, including increasing antimicrobial resistance and late GBS infection after negative antenatal screening. Maternal immunization is the most promising and effective countermeasure against GBS infection in neonates. However, no vaccine is available to date, but two types of vaccines, protein subunit and capsular polysaccharide conjugate vaccines, were investigated in clinical trials. Here, we provide an overview of the GBS vaccine development status and recent advances in the development of immunoassays to evaluate the GBS vaccine clinical efficacy.

Original languageEnglish
Pages (from-to)2669-2681
Number of pages13
JournalHuman Vaccines and Immunotherapeutics
Volume14
Issue number11
DOIs
StatePublished - 2 Nov 2018

Bibliographical note

Funding Information:
This work was supported by the Nuclear R&D program of Ministry of Science and ICT the Ministry of Food and Drug Administration (18172MFDS253) National Research Foundation of Korea (2015R1D1A1A01059338) National Research Foundation of Korea (NRF-2017M2A2A6A02020925) This work was supported by the Nuclear R&D program of Ministry of Science and ICT (S.L); National Research Foundation of Korea under Grants NRF-2017M2A2A6A02020925 to HSS and 2015R1D1A1A01059338 to JHL; and the Ministry of Food and Drug Administration under Grant 18172MFDS253 to JYS.

Publisher Copyright:
© 2018, © 2018 The Author(s). Published with license by Taylor & Francis.

Keywords

  • Streptococcus agalactiae
  • group B Streptococcus
  • maternal immunization
  • vaccine

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