Prognostic Value of Percentage Change in Metabolic Parameters as Measured by Dual-Time Point 18F-FDG PET/CT in Premenopausal Women with Invasive Ductal Breast Carcinoma

Jang Yoo; Hai Jeon Yoon; Bom Sahn Kim

doi:10.1089/jwh.2016.6256

Prognostic Value of Percentage Change in Metabolic Parameters as Measured by Dual-Time Point ¹⁸F-FDG PET/CT in Premenopausal Women with Invasive Ductal Breast Carcinoma

Jang Yoo, Hai Jeon Yoon, Bom Sahn Kim

Department of Nuclear Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Objectives: We retrospectively evaluated the prognostic significance of dual-time point (DTP) ¹⁸F-FDG positron emission tomography/computed tomography (PET/CT) parameters compared with clinicopathological findings in premenopausal women with invasive ductal breast carcinoma (IDC). Materials and Methods: Sixty-six premenopausal women (mean age: 42.7 ± 5.6, range: 29.5-51.8 years) who had pathologically confirmed IDC were enrolled. The maximum standardized uptake value (SUV_max), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and used to calculate percentage changes over the DTP time interval. We analyzed the prognostic significance of DTP PET/CT parameters, clinicopathological factors of pathologic tumor diameter (pTD), axillary lymph node status (ANS), nuclear grade, histologic grade, and immunohistochemistry findings using univariate and multivariate analyses. Results: Disease recurrence was observed in 22 patients. In univariate analysis, SUV_max > 7.39, MTV > 4.28, TLG > 52.38, %ΔSUV_max > 20.44, %ΔTLG >-13.86, pTD > 2.8 cm, positive ANS, estrogen receptor (ER) negativity, and triple negativity were associated with worse prognosis than those of opposite groups in recurrence-free survival (all p < 0.05). %ΔSUV_max (>20.44, p = 0.0042), TLG (>52.38, p = 0.0002), and ER negativity (p = 0.0003) were independent prognostic variables after multivariate analysis. Conclusion: Percentage changes in SUV_max using DTP PET/CT and TLG were significant independent prognostic factors of disease recurrence along with ER negativity in premenopausal women with IDC.

Original language	English
Pages (from-to)	1131-1137
Number of pages	7
Journal	Journal of Women's Health
Volume	26
Issue number	10
DOIs	https://doi.org/10.1089/jwh.2016.6256
State	Published - Oct 2017

Bibliographical note

Funding Information:
The scientific guarantor of this publication is B.S.K. The authors of this article have no relationships to declare with any companies whose products or services may be related to the subject matter of the article. This research was supported by grants from the National Research Foundation (2015R1C1 A1A02037051, 2012M3A9B6055379, NRF-2015R1C1A2A 01054113). Institutional review board approval was obtained and written informed consent was waived.

Publisher Copyright:
© 2017, Mary Ann Liebert, Inc.

Keywords

dual time point 18F-FDG PET/CT
invasive ductal breast carcinoma
metabolic tumor volume
prognosis
recurrence-free survival

Access to Document

10.1089/jwh.2016.6256

Cite this

@article{cab3e5cc401d4a1aad2769c0e066cb8b,

title = "Prognostic Value of Percentage Change in Metabolic Parameters as Measured by Dual-Time Point 18F-FDG PET/CT in Premenopausal Women with Invasive Ductal Breast Carcinoma",

abstract = "Objectives: We retrospectively evaluated the prognostic significance of dual-time point (DTP) 18F-FDG positron emission tomography/computed tomography (PET/CT) parameters compared with clinicopathological findings in premenopausal women with invasive ductal breast carcinoma (IDC). Materials and Methods: Sixty-six premenopausal women (mean age: 42.7 ± 5.6, range: 29.5-51.8 years) who had pathologically confirmed IDC were enrolled. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and used to calculate percentage changes over the DTP time interval. We analyzed the prognostic significance of DTP PET/CT parameters, clinicopathological factors of pathologic tumor diameter (pTD), axillary lymph node status (ANS), nuclear grade, histologic grade, and immunohistochemistry findings using univariate and multivariate analyses. Results: Disease recurrence was observed in 22 patients. In univariate analysis, SUVmax > 7.39, MTV > 4.28, TLG > 52.38, %ΔSUVmax > 20.44, %ΔTLG >-13.86, pTD > 2.8 cm, positive ANS, estrogen receptor (ER) negativity, and triple negativity were associated with worse prognosis than those of opposite groups in recurrence-free survival (all p < 0.05). %ΔSUVmax (>20.44, p = 0.0042), TLG (>52.38, p = 0.0002), and ER negativity (p = 0.0003) were independent prognostic variables after multivariate analysis. Conclusion: Percentage changes in SUVmax using DTP PET/CT and TLG were significant independent prognostic factors of disease recurrence along with ER negativity in premenopausal women with IDC.",

keywords = "dual time point 18F-FDG PET/CT, invasive ductal breast carcinoma, metabolic tumor volume, prognosis, recurrence-free survival",

author = "Jang Yoo and Yoon, {Hai Jeon} and Kim, {Bom Sahn}",

note = "Funding Information: The scientific guarantor of this publication is B.S.K. The authors of this article have no relationships to declare with any companies whose products or services may be related to the subject matter of the article. This research was supported by grants from the National Research Foundation (2015R1C1 A1A02037051, 2012M3A9B6055379, NRF-2015R1C1A2A 01054113). Institutional review board approval was obtained and written informed consent was waived. Publisher Copyright: {\textcopyright} 2017, Mary Ann Liebert, Inc.",

year = "2017",

month = oct,

doi = "10.1089/jwh.2016.6256",

language = "English",

volume = "26",

pages = "1131--1137",

journal = "Journal of Women's Health",

issn = "1540-9996",

publisher = "Mary Ann Liebert Inc.",

number = "10",

}

TY - JOUR

T1 - Prognostic Value of Percentage Change in Metabolic Parameters as Measured by Dual-Time Point 18F-FDG PET/CT in Premenopausal Women with Invasive Ductal Breast Carcinoma

AU - Yoo, Jang

AU - Yoon, Hai Jeon

AU - Kim, Bom Sahn

N1 - Funding Information: The scientific guarantor of this publication is B.S.K. The authors of this article have no relationships to declare with any companies whose products or services may be related to the subject matter of the article. This research was supported by grants from the National Research Foundation (2015R1C1 A1A02037051, 2012M3A9B6055379, NRF-2015R1C1A2A 01054113). Institutional review board approval was obtained and written informed consent was waived. Publisher Copyright: © 2017, Mary Ann Liebert, Inc.

PY - 2017/10

Y1 - 2017/10

N2 - Objectives: We retrospectively evaluated the prognostic significance of dual-time point (DTP) 18F-FDG positron emission tomography/computed tomography (PET/CT) parameters compared with clinicopathological findings in premenopausal women with invasive ductal breast carcinoma (IDC). Materials and Methods: Sixty-six premenopausal women (mean age: 42.7 ± 5.6, range: 29.5-51.8 years) who had pathologically confirmed IDC were enrolled. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and used to calculate percentage changes over the DTP time interval. We analyzed the prognostic significance of DTP PET/CT parameters, clinicopathological factors of pathologic tumor diameter (pTD), axillary lymph node status (ANS), nuclear grade, histologic grade, and immunohistochemistry findings using univariate and multivariate analyses. Results: Disease recurrence was observed in 22 patients. In univariate analysis, SUVmax > 7.39, MTV > 4.28, TLG > 52.38, %ΔSUVmax > 20.44, %ΔTLG >-13.86, pTD > 2.8 cm, positive ANS, estrogen receptor (ER) negativity, and triple negativity were associated with worse prognosis than those of opposite groups in recurrence-free survival (all p < 0.05). %ΔSUVmax (>20.44, p = 0.0042), TLG (>52.38, p = 0.0002), and ER negativity (p = 0.0003) were independent prognostic variables after multivariate analysis. Conclusion: Percentage changes in SUVmax using DTP PET/CT and TLG were significant independent prognostic factors of disease recurrence along with ER negativity in premenopausal women with IDC.

AB - Objectives: We retrospectively evaluated the prognostic significance of dual-time point (DTP) 18F-FDG positron emission tomography/computed tomography (PET/CT) parameters compared with clinicopathological findings in premenopausal women with invasive ductal breast carcinoma (IDC). Materials and Methods: Sixty-six premenopausal women (mean age: 42.7 ± 5.6, range: 29.5-51.8 years) who had pathologically confirmed IDC were enrolled. The maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured and used to calculate percentage changes over the DTP time interval. We analyzed the prognostic significance of DTP PET/CT parameters, clinicopathological factors of pathologic tumor diameter (pTD), axillary lymph node status (ANS), nuclear grade, histologic grade, and immunohistochemistry findings using univariate and multivariate analyses. Results: Disease recurrence was observed in 22 patients. In univariate analysis, SUVmax > 7.39, MTV > 4.28, TLG > 52.38, %ΔSUVmax > 20.44, %ΔTLG >-13.86, pTD > 2.8 cm, positive ANS, estrogen receptor (ER) negativity, and triple negativity were associated with worse prognosis than those of opposite groups in recurrence-free survival (all p < 0.05). %ΔSUVmax (>20.44, p = 0.0042), TLG (>52.38, p = 0.0002), and ER negativity (p = 0.0003) were independent prognostic variables after multivariate analysis. Conclusion: Percentage changes in SUVmax using DTP PET/CT and TLG were significant independent prognostic factors of disease recurrence along with ER negativity in premenopausal women with IDC.

KW - dual time point 18F-FDG PET/CT

KW - invasive ductal breast carcinoma

KW - metabolic tumor volume

KW - prognosis

KW - recurrence-free survival

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U2 - 10.1089/jwh.2016.6256

DO - 10.1089/jwh.2016.6256

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AN - SCOPUS:85031675709

SN - 1540-9996

VL - 26

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