Prognostic significance of neutropenia during adjuvant concurrent chemoradiotherapy in early cervical cancer

Hwan Kim Yun, Hoon Chung Hyun, Weon Kim Jae, Noh Hyun Park, Yong Sang Song, Soon Beom Kang

Research output: Contribution to journalArticlepeer-review

16 Scopus citations


Objective: To evaluate the prognostic significance of adjuvant concurrent chemoradiotherapy-induced neutropenia with survival in patients with squamous cell carcinoma of the uterine cervix. Methods: Data from 107 patients with stage IB-IIB cervical cancer were retrospectively analyzed. The median follow-up was 37.5 (4.2-72.7) months. All patients had received radical surgery, including pelvic lymphadenectomy, followed by paclitaxel plus carboplatin-based concurrent chemoradiotherapy. Relative neutropenia, defined as an absolute neutrophil count <1,000/mm3 at the concurrent chemoradiotherapy cycle nadir, correlated to the pathologic findings and survival outcomes. Results: Sixty-six patients experienced neutropenia at least once during concurrent chemoradiotherapy, and demonstrated marginal improvement in disease-free survival (p=0.055), although not in overall survival. By subgroup analyses, the gain of disease free survival mainly originated from the node metastasis subgroup (p=0.033). Treatment-induced neutropenia proved to be the only significant independent factor for recurrence in cervical cancer (p=0.042) by multivariate analysis. Conclusion: Concurrent chemoradiotherapy-induced neutropenia may be a prognostic factor of recurrence in patients with cervical cancer. Individualized dose titration of the tolerable myelosuppression might be beneficial.

Original languageEnglish
Pages (from-to)146-150
Number of pages5
JournalJournal of Gynecologic Oncology
Issue number3
StatePublished - Sep 2009


  • Chemoradiotherapy
  • Neutropenia
  • Survival
  • Uterine cervical cancer


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