Prognostic significance of Ki-67 expression in patients undergoing surgical resection for gastrointestinal stromal tumor

Seong Y.eon Jeong; Won W.o. Park; You S.un Kim; Young I.l. Park; Seung H.yup Kim; Won J.ae Yoon; Jeong S.eop Moon; Byung M.o. Lee; Seong W.oo Hong; Yun K.yung Kang

doi:10.4166/kjg.2014.64.2.87

Prognostic significance of Ki-67 expression in patients undergoing surgical resection for gastrointestinal stromal tumor

Seong Y.eon Jeong, Won W.o. Park, You S.un Kim, Young I.l. Park, Seung H.yup Kim, Won J.ae Yoon, Jeong S.eop Moon, Byung M.o. Lee, Seong W.oo Hong, Yun K.yung Kang

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

BACKGROUND/AIMS: Assessment of malignant potential in gastrointestinal stromal tumor (GIST) is still problematic. The maximum tumor diameter and the mitotic index are generally used as an index of malignancy of GISTs. The Ki-67 labeling index has recently been used as an index of cell growth. The aim of this study was to investigate the prognostic value of Ki-67 in GIST.

METHODS: We retrospectively reviewed the medical records of 32 patients with GIST who underwent surgical resection at Inje University Seoul Paik Hospital. We analyzed their Ki-67 expression, histologic finding, and prognosis.

RESULTS: According to the tumor size and mitotic count, 4 patients were classified as very low risk, 9 patients as low risk, 14 patients as intermediate risk and 5 patients as high risk. The average Ki-67 index was 5.56±4.48%. The median follow-up duration was 35.72±29.04 months, and local/distant recurrences were observed in 6 (18.7%) patients. The overall cumulative disease free survival rates in patients with Ki-67 index ≤5% at 1 year, 2 years, and 5 years were 100%, 100%, and 86%, respectively. The overall cumulative disease free survival rates in patients with Ki-67 index >5% were at 1 year, 2 years, and 5 years were 82.1%, 70.3%, and 46.9%, respectively. There was significant relationship between elevated Ki-67 and disease free survival rate (p=0.007).

CONCLUSIONS: Our study suggests that Ki-67 index >5% confers a higher risk of relapse in patients with GIST. Future work should focus on standardization of Ki-67 assessment and specification of its role in making treatment decisions.

Original language	English
Pages (from-to)	87-92
Number of pages	6
Journal	The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi
Volume	64
Issue number	2
DOIs	https://doi.org/10.4166/kjg.2014.64.2.87
State	Published - 1 Aug 2014

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Jeong, S. Y. E., Park, W. W. O., Kim, Y. S. U., Park, Y. I. L., Kim, S. H. Y., Yoon, W. J. A., Moon, J. S. E., Lee, B. M. O., Hong, S. W. O., & Kang, Y. K. Y. (2014). Prognostic significance of Ki-67 expression in patients undergoing surgical resection for gastrointestinal stromal tumor. The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 64(2), 87-92. https://doi.org/10.4166/kjg.2014.64.2.87

@article{51f2264c496a4e36bc2944f839af814b,

title = "Prognostic significance of Ki-67 expression in patients undergoing surgical resection for gastrointestinal stromal tumor",

abstract = "BACKGROUND/AIMS: Assessment of malignant potential in gastrointestinal stromal tumor (GIST) is still problematic. The maximum tumor diameter and the mitotic index are generally used as an index of malignancy of GISTs. The Ki-67 labeling index has recently been used as an index of cell growth. The aim of this study was to investigate the prognostic value of Ki-67 in GIST.METHODS: We retrospectively reviewed the medical records of 32 patients with GIST who underwent surgical resection at Inje University Seoul Paik Hospital. We analyzed their Ki-67 expression, histologic finding, and prognosis.RESULTS: According to the tumor size and mitotic count, 4 patients were classified as very low risk, 9 patients as low risk, 14 patients as intermediate risk and 5 patients as high risk. The average Ki-67 index was 5.56±4.48%. The median follow-up duration was 35.72±29.04 months, and local/distant recurrences were observed in 6 (18.7%) patients. The overall cumulative disease free survival rates in patients with Ki-67 index ≤5% at 1 year, 2 years, and 5 years were 100%, 100%, and 86%, respectively. The overall cumulative disease free survival rates in patients with Ki-67 index >5% were at 1 year, 2 years, and 5 years were 82.1%, 70.3%, and 46.9%, respectively. There was significant relationship between elevated Ki-67 and disease free survival rate (p=0.007).CONCLUSIONS: Our study suggests that Ki-67 index >5% confers a higher risk of relapse in patients with GIST. Future work should focus on standardization of Ki-67 assessment and specification of its role in making treatment decisions.",

author = "Jeong, {Seong Y.eon} and Park, {Won W.o.} and Kim, {You S.un} and Park, {Young I.l.} and Kim, {Seung H.yup} and Yoon, {Won J.ae} and Moon, {Jeong S.eop} and Lee, {Byung M.o.} and Hong, {Seong W.oo} and Kang, {Yun K.yung}",

year = "2014",

month = aug,

day = "1",

doi = "10.4166/kjg.2014.64.2.87",

language = "English",

volume = "64",

pages = "87--92",

journal = "The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi",

issn = "1598-9992",

publisher = "Korean Society of Gastroenterology",

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Jeong, SYE, Park, WWO, Kim, YSU, Park, YIL, Kim, SHY, Yoon, WJA, Moon, JSE, Lee, BMO, Hong, SWO & Kang, YKY 2014, 'Prognostic significance of Ki-67 expression in patients undergoing surgical resection for gastrointestinal stromal tumor', The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, vol. 64, no. 2, pp. 87-92. https://doi.org/10.4166/kjg.2014.64.2.87

TY - JOUR

T1 - Prognostic significance of Ki-67 expression in patients undergoing surgical resection for gastrointestinal stromal tumor

AU - Jeong, Seong Y.eon

AU - Park, Won W.o.

AU - Kim, You S.un

AU - Park, Young I.l.

AU - Kim, Seung H.yup

AU - Yoon, Won J.ae

AU - Moon, Jeong S.eop

AU - Lee, Byung M.o.

AU - Hong, Seong W.oo

AU - Kang, Yun K.yung

PY - 2014/8/1

Y1 - 2014/8/1

N2 - BACKGROUND/AIMS: Assessment of malignant potential in gastrointestinal stromal tumor (GIST) is still problematic. The maximum tumor diameter and the mitotic index are generally used as an index of malignancy of GISTs. The Ki-67 labeling index has recently been used as an index of cell growth. The aim of this study was to investigate the prognostic value of Ki-67 in GIST.METHODS: We retrospectively reviewed the medical records of 32 patients with GIST who underwent surgical resection at Inje University Seoul Paik Hospital. We analyzed their Ki-67 expression, histologic finding, and prognosis.RESULTS: According to the tumor size and mitotic count, 4 patients were classified as very low risk, 9 patients as low risk, 14 patients as intermediate risk and 5 patients as high risk. The average Ki-67 index was 5.56±4.48%. The median follow-up duration was 35.72±29.04 months, and local/distant recurrences were observed in 6 (18.7%) patients. The overall cumulative disease free survival rates in patients with Ki-67 index ≤5% at 1 year, 2 years, and 5 years were 100%, 100%, and 86%, respectively. The overall cumulative disease free survival rates in patients with Ki-67 index >5% were at 1 year, 2 years, and 5 years were 82.1%, 70.3%, and 46.9%, respectively. There was significant relationship between elevated Ki-67 and disease free survival rate (p=0.007).CONCLUSIONS: Our study suggests that Ki-67 index >5% confers a higher risk of relapse in patients with GIST. Future work should focus on standardization of Ki-67 assessment and specification of its role in making treatment decisions.

AB - BACKGROUND/AIMS: Assessment of malignant potential in gastrointestinal stromal tumor (GIST) is still problematic. The maximum tumor diameter and the mitotic index are generally used as an index of malignancy of GISTs. The Ki-67 labeling index has recently been used as an index of cell growth. The aim of this study was to investigate the prognostic value of Ki-67 in GIST.METHODS: We retrospectively reviewed the medical records of 32 patients with GIST who underwent surgical resection at Inje University Seoul Paik Hospital. We analyzed their Ki-67 expression, histologic finding, and prognosis.RESULTS: According to the tumor size and mitotic count, 4 patients were classified as very low risk, 9 patients as low risk, 14 patients as intermediate risk and 5 patients as high risk. The average Ki-67 index was 5.56±4.48%. The median follow-up duration was 35.72±29.04 months, and local/distant recurrences were observed in 6 (18.7%) patients. The overall cumulative disease free survival rates in patients with Ki-67 index ≤5% at 1 year, 2 years, and 5 years were 100%, 100%, and 86%, respectively. The overall cumulative disease free survival rates in patients with Ki-67 index >5% were at 1 year, 2 years, and 5 years were 82.1%, 70.3%, and 46.9%, respectively. There was significant relationship between elevated Ki-67 and disease free survival rate (p=0.007).CONCLUSIONS: Our study suggests that Ki-67 index >5% confers a higher risk of relapse in patients with GIST. Future work should focus on standardization of Ki-67 assessment and specification of its role in making treatment decisions.

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DO - 10.4166/kjg.2014.64.2.87

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C2 - 25168050

AN - SCOPUS:84973434351

SN - 1598-9992

VL - 64

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EP - 92

JO - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

JF - The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi

IS - 2

ER -

Prognostic significance of Ki-67 expression in patients undergoing surgical resection for gastrointestinal stromal tumor

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