TY - JOUR
T1 - Prognostic role of the MicroRNA-200 family in various carcinomas
T2 - A systematic review and meta-analysis
AU - Lee, Jung Soo
AU - Ahn, Young Ho
AU - Won, Hye Sung
AU - Sun, Der Sheng
AU - Kim, Yeo Hyung
AU - Ko, Yoon Ho
N1 - Funding Information:
This study was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (NRF-2015R1C1A1A01054591) (Yoon Ho Ko)
Publisher Copyright:
© Copyright 2017 Jung Soo Lee et al.
PY - 2017
Y1 - 2017
N2 - Background/Aims. The miRNA-200 (miR-200) family may act as key inhibitors of epithelial-to-mesenchymal transition. However, the potential prognostic value of miR-200s in various human malignancies remains controversial. This meta-analysis analyzed the associations between miR-200 levels and survival outcomes in a variety of tumors. Methods. Eligible published studies were identified by searching theEmbase, PubMed, CINAHL, andGoogle scholar databases. Patient clinical data were pooled, and pooled hazard ratios (HRs) with 95% confidence intervals (95% CI) were used to calculate the strength of this association. Results. The pooled HRs suggested that high tissue expression of miR-200 family members was associated with better survival (overall survival [OS]: HR = 0.70, 95% CI 0.54-0.91; progression-free survival [PFS]: HR = 0.63, 95% CI 0.52-0.76) in thirty-four eligible articles. In contrast, higher expression of circulating miR-200 members was significantly associated with poor clinical outcome (OS, HR = 1.68, 95% CI 1.15-2.46; PFS, HR = 2.62, 95% CI 1.68-4.07). Conclusion. The results from this meta-analysis suggest that miR-200 family members are potential prognostic biomarkers in patients with various carcinomas. To apply these findings in the clinic, large prospective studies are needed to validate the prognostic values of miR-200s in individual cancer types.
AB - Background/Aims. The miRNA-200 (miR-200) family may act as key inhibitors of epithelial-to-mesenchymal transition. However, the potential prognostic value of miR-200s in various human malignancies remains controversial. This meta-analysis analyzed the associations between miR-200 levels and survival outcomes in a variety of tumors. Methods. Eligible published studies were identified by searching theEmbase, PubMed, CINAHL, andGoogle scholar databases. Patient clinical data were pooled, and pooled hazard ratios (HRs) with 95% confidence intervals (95% CI) were used to calculate the strength of this association. Results. The pooled HRs suggested that high tissue expression of miR-200 family members was associated with better survival (overall survival [OS]: HR = 0.70, 95% CI 0.54-0.91; progression-free survival [PFS]: HR = 0.63, 95% CI 0.52-0.76) in thirty-four eligible articles. In contrast, higher expression of circulating miR-200 members was significantly associated with poor clinical outcome (OS, HR = 1.68, 95% CI 1.15-2.46; PFS, HR = 2.62, 95% CI 1.68-4.07). Conclusion. The results from this meta-analysis suggest that miR-200 family members are potential prognostic biomarkers in patients with various carcinomas. To apply these findings in the clinic, large prospective studies are needed to validate the prognostic values of miR-200s in individual cancer types.
UR - http://www.scopus.com/inward/record.url?scp=85016022916&partnerID=8YFLogxK
U2 - 10.1155/2017/1928021
DO - 10.1155/2017/1928021
M3 - Review article
C2 - 28321402
AN - SCOPUS:85016022916
SN - 2314-6133
VL - 2017
JO - BioMed Research International
JF - BioMed Research International
M1 - 1928021
ER -