Prognostic role of serum lactate dehydrogenase beyond initial diagnosis: A retrospective analysis of patients with diffuse large B cell lymphoma

Junshik Hong, Hyun Hwa Yoon, Hee Kyung Ahn, Sun Jin Sym, Jinny Park, Pil Whan Park, Jeong Yeal Ahn, Sanghui Park, Eun Kyung Cho, Dong Bok Shin, Jae Hoon Lee

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

Background/Aims: Baseline serum lactate dehydrogenase (LDH) level is a well-known prognostic factor in patients with non-Hodgkin's lymphoma; however, its role beyond initial diagnosis has not yet been defined. Methods: This study was conducted as a retrospective analysis of patients with diffuse large B cell lymphoma (DLBCL) treated with R-CHOP21, who had undergone regular checks for LDH during immunochemotherapy (n = 119) and during the posttreatment follow-up period after complete remission (CR; n = 100). The 119 patients were classified into 4 groups according to their baseline and change in LDH level during treatment, and an analysis of tumor response and survival was performed. The value of LDH as a predictor for relapse was evaluated among the patients with regular follow-up visits after achieving CR. Results: An increased LDH level during immunochemotherapy had no impact on tumor response or survival, and only the LDH status 'before' treatment was a prognostic marker. The sensitivity, specificity, positive predictive value and negative predictive value of serum LDH for detecting relapse after CR were 47.4, 86.5, 9.3 and 98.3%, respectively. Conclusion: The measurement of LDH level beyond initial diagnosis has no clear benefit in predicting disease progression or relapse in patients with DLBCL treated with R-CHOP21.

Original languageEnglish
Pages (from-to)305-311
Number of pages7
JournalActa Haematologica
Volume130
Issue number4
DOIs
StatePublished - Nov 2013

Keywords

  • Diffuse large B cell lymphoma
  • Lactate dehydrogenase
  • Non-Hodgkin lymphoma
  • Prognosis

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