Prognostic implications of tumor extent in early-stage diffuse large B-cell lymphoma

Changhoon Yoo, Dok Hyun Yoon, Jeong Eun Kim, Jungmin Jo, Seong Joon Park, Shin Kyo Yoon, Yongchel Ahn, Shin Kim, Jooryung Huh, Dae Ho Lee, Cheolwon Suh

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Therapeutic strategies for early-stage diffuse large B-cell lymphoma (DLBCL) are often influenced by tumor extent, but the prognostic value of this parameter is rarely defined. Here, a retrospective analysis was performed to define the impact of tumor extent on survival of patients with early-stage DLBCL. Eighty-six patients with stage II DLBCL, diagnosed from 2000-2007, were categorized into localized (n = 55, 64 %) and disseminated groups (n = 31, 36 %) based on tumor extent at time of diagnosis. Treatment modalities, chemotherapy regimen and number of chemotherapy cycles were the same between groups. With a median follow-up of 7.6 years (range 2.1-12.1 years), overall 5-year event-free survival (EFS) and overall survival (OS) were 70.6 and 76.5 %, respectively. EFS (P = 1.00) and OS (P = 0.20) did not differ between the two groups. Older age (>60 years) was significantly associated with poor EFS (P = 0.01) and OS (P = 0.04). High-risk patients as rated by stage-modified international prognostic index (IPI) had inferior EFS (P = 0.04) and OS (P = 0.06) compared with the intermediate- risk group. These results indicate that tumor extent has no prognostic value in patients with early-stage DLBCL. Consistent with previous studies, age and stagemodified IPI were useful prognostic indices for these patients.

Original languageEnglish
Pages (from-to)232-239
Number of pages8
JournalInternational Journal of Hematology
Issue number2
StatePublished - Feb 2013


  • Diffuse large b-cell lymphoma
  • Disseminated
  • Localized
  • Prognosis
  • Tumor extent


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