Prognostic application of thoracic aortic calcium scoring for adverse clinical outcome risk in elderly patients with left ventricular hypertrophy

In Jeong Cho, Hyuk Jae Chang, Sang Eun Lee, Chi Young Shim, Geu Ru Hong, Namsik Chung

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Background and Objectives: Left ventricular hypertrophy (LVH) is associated with poor cardiovascular outcomes. Heavy aortic calcification exacerbates arterial stiffness, which consequently heightens left ventricular (LV) afterload. We assessed the usefulness of aortic calcification for predicting adverse cardiovascular outcomes and to determine whether the relationship, if any, differed as a function of LVH. Methods: The analytic sample was comprised of a total of 487 individuals 65 years of age or older. Thoracic aortic calcium score (TACS) was measured by coronary computed tomography, and patients were stratified according to the median (TACS, 446 mm3). LVH obtained from echocardiography was defined as LV mass index >115 g/m2 for men and >95 g/m2 for women. Cox regression reporting hazard ratios (HRs) with 95% confidence intervals (CIs) was performed to predict the risk for the composite study endpoint, defined as cardiac death, admission for heart failure, obstructive coronary artery disease (CAD) requiring revascularization, or stroke. Results: A total of 39 composite events (8.0%) occurred during a median follow-up of 65 months (interquartile range [IQR], 17-89 months). For those with LVH, the concurrent presence of high TACS appeared to be an independent predictor (HR, 4.51; 95% CI, 1.71-11.88; p=0.002) for the composite study endpoint. Other combined LVH and TACS subgroups were not associated with significant factors for predicting the composite study endpoint (p>0.050, all). Conclusion: TACS provides robust predictive utility for a composite of cardiovascular events and cardiac death in persons with LVH. This finding was less pronounced in those with a relatively healthy myocardium, defined by the absence of LVH.

Original languageEnglish
Pages (from-to)918-928
Number of pages11
JournalKorean Circulation Journal
Issue number6
StatePublished - Nov 2017

Bibliographical note

Funding Information:
This research was supported by the Leading Foreign Research Institute Recruitment Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning (MSIP) (No. 2012027176).

Publisher Copyright:
© 2017. The Korean Society of Cardiology.


  • Left ventricular hypertrophy
  • Prognosis
  • Vascular calcification


Dive into the research topics of 'Prognostic application of thoracic aortic calcium scoring for adverse clinical outcome risk in elderly patients with left ventricular hypertrophy'. Together they form a unique fingerprint.

Cite this