Profiles of COX-2 inhibitors: Present and future

Shin Chung, Kyung Min Lim, Song Seok Shin

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Cyclooxygenases are responsible for the biosynthesis of prostanoids, the overt presence of which is often associated with inflammation and pain. Since the discovery of COX-2 in the last decade, a myriad of selective COX-2 inhibitors and their pharmacological profiles have been witnessed. Pharmacological observations of selective inhibition of COX-2 often go beyond initial expectations. This review is an overview of issues on selective COX-2 inhibitors, which include gastrointestinal and cardiovascular safety, emerging therapeutic areas and differentiation in drug profiles expected to be addressed by future generation COX-2 inhibitors. This article also covers recent patents and papers on new COX-2 inhibitors published since 2002. Future generation COX-2 inhibitors are sure to be safer and meet better medical needs than the COX-2 inhibitors currently available for the treatment or prevention of broadly ranged COX-2-mediated disorders.

Original languageEnglish
Pages (from-to)9-32
Number of pages24
JournalExpert Opinion on Therapeutic Patents
Issue number1
StatePublished - Jan 2005

Bibliographical note

Funding Information:
This work was partially supported by a grant of The Korean Health 21 R&D Project (code number: 0405-DD00-0101-003) from Ministry of Health & Welfare, Republic of Korea.


  • Cancer
  • Cardiorenal safety
  • COX-2
  • Cyclooxygenase
  • Inflammation
  • Pain


Dive into the research topics of 'Profiles of COX-2 inhibitors: Present and future'. Together they form a unique fingerprint.

Cite this